摘要
对２５例急性心肌梗塞（ＡＭＩ）并左心功能不全患者早期应用血管紧张素转换酶抑制剂（ＡＣＥＩ）治疗的对照性临床分析，结果：用小剂量的ＡＣＥＩ治疗对患者心率、血压无显著的影响〔治疗前后心率分别为８９．９０±１０．２２次／分与８９．４２±８．１９次／分，血压分别为１５．３７±３．４６／９．７４±２．３２ｋＰａ（１ｋＰａ＝７．５ｍｍＨｇ）〕和１４．９６±２．６０／９．４６±１．７６ｋＰａ〕；对合并轻、中度泵衰竭患者的疗效显著，但对重度泵衰竭的疗效与对照组比较无显著性差异；治疗组恶性心律失常的发生率较对照组减低１３．３８％，警告性室早的发生率治疗组较对照组减少２６．３９％，但Ⅱ°～Ⅲ°房室传导阻滞的发生率治疗组高于对照组；两组４周病死率比较无显著性差异。作者认为：ＡＣＥＩ治疗ＡＭＩ并轻、中度泵衰竭安全有效；ＡＣＥＩ有一定抗心律失常作用，但应注意传导系统的并发症，使用中应注意各种副作用的发生。
The controlled clinical analysis of 25 cases in acute myocardial infartion(AMI) complicated by left ventricular failure treated with captopril in early intervention showed no significant changes of heart rate and blood pressure were found in the use of lower dosage captopril.On average,the heart rate was 89.90±10.22 before using captopril and was 89.42±8.12 after using it ( P >0.05);the diastolic blood pressure was 15.37± 3.46 before using captopril and was 14.96±2.60 after using it( P >0.05);the systolic blood pressure was 9.74 ±2.32 before using captopril and was 9.46±1.76 after using it( P >0.05).The significant effects were found in those with mild and moderate heart failure,but no significant effects were found in those with severe heart failure.the morbidity of serious arrhythmias was decreased by 13.38% and the morbidity of the warning ventricular premature beats was decreased by 26.39% in the captopril group as compared with the control group.But the morbidity of the second and third degree atrioventricular block in captopril group was higher than the control group.No significant difference was found in 4 weeks' mortality between both groups.The analysis suggests that catopril is safe and useful in AMI with mild and moderate heart failure.Captopril decreases the morbidity of serious arrhythmias in the treatment of AMI.Care must be taken to avoid the complication in conduction system and other side effects.
出处
《中国危重病急救医学》
CAS
CSCD
1996年第2期91-93,共3页
Chinese Critical Care Medicine
关键词
血管紧张素
转换酶
抑制剂
心肌梗塞
angiotensin converting enzyme inhibitor
myocardial infarction
left ventricular function
