摘要
目的研究锌与胃癌的发病关系。方法用电感耦合等离子体原子发射光谱法(ICP-AES)检测锌的含量,同时用免疫组化链霉卵-生物素-辣根过氧化酶复合物法(SP法)观察Cox-2的表达。结果发现胃癌病人血清中锌与健康对照组相比有所不同,胃癌组Zn2+、M n2+低于健康对照组(P<0.05),Cox-2阳性组锌的含量明显低于Cox-2阴性组(P<0.05)。结论血清锌降低对胃癌发病是个关键的因素。
Objective To study the relation of the level serum zinc with the development gastric carcinoma. Methods An inductively coupled plasma atomic emissions spectrometry （ICP-AES,ARL-3520 USA） was use to detect the zinc element, strep tavidin-peroxidase（SP） was used to detect the expression of cyclooxygenase-2（Cox-2）. Results There were some different zinc elements levels in serum between gastric carcinoma patients and healthy volunteers,the levels of Zn^2＋ and Mn^2＋ in gastric carcinoma groups were lower than healthy volunteers groups （P〈0. 05）,the levels of Zn^2＋ significantly was lower in Cox-2 positive groups than negative groups （P〈0. 05）. Conclusion It showed that deficiency of Zn^2＋ in serum is a key factor of occurrence of gastric carcinoma.
出处
《现代检验医学杂志》
CAS
2006年第2期29-30,共2页
Journal of Modern Laboratory Medicine
关键词
胃癌
锌
环氧化酶-2
gastric carcinoma
Zn^2＋
cyclooxygenase-2
