摘要
目的总结并探讨涎腺上皮-肌上皮癌的病理学特点及治疗方法。方法回顾分析1964至2004年14例涎腺上皮-肌上皮癌患者的病理和临床治疗资料,其中腮腺8例,硬腭2例,颌下腺3例,鼻腔1例。1例行姑息性放疗,13例行根治性手术,3例行术前诱导化疗,6例行术后放疗。结果涎腺上皮-肌上皮癌好发于腮腺,颈部淋巴转移率14.28%(2/14),采用Kaplan-Meier法行生存率分析,3年、5年及10年累积生存率分别为67.20%、45.49%、17.06%。肿瘤由内层腺上皮细胞和外层透明肌上皮细胞构成为主要特点,免疫组化示细胞角蛋白、S-100蛋白及肌动蛋白呈阳性反应。结论涎腺上皮-肌上皮癌治疗后容易复发,对放疗和化疗有一定敏感性,宜采用以手术为主的综合治疗。
Objective To review and evaluate pathologic features and treatment of epithelialmyoepithelial. Methods Retrospectively reviewed 14 cases＇ pathological and clinical materials of epithelialmyoepithelial carcinoma of salivary gland. Eight cases origined from parotid gland, 2 cases from hard palate, 3 cases from submandibular gland and 1 case from nasal cavity. Three cases were performed induction chemotherapy preoperation. One case had palliative radiotherapy. Thirteen cases were performed radical surgery and 6 cases had radiotherapy postoperation. Results Tumor arisen mostly from parotid gland and neck lymph node metastasis rate was 14. 28% （2/14）. The survival rate was calculated with Kaplan-Meier method. The overall 3-, 5- and 10-year survival rate were 67. 20%, 45.49% and 17.06%. Its histological characteristics were inner layer composed by adenoid cells and outer layer composed by myoepithelial cells. Immunohistochemical exam show cytokeratin, S-IO0 and actin reaction positive. Conduslons Epithelial- myoepithelial carcinoma easily develops recurrence. It is sensitivity to radiotherapy and chemotherapy to some extent. It is suitable to adopt surgical treatment as primary modality combined with other therapies.
出处
《中华耳鼻咽喉头颈外科杂志》
CAS
CSCD
北大核心
2006年第4期281-283,共3页
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
关键词
涎腺肿瘤
病理学
综合疗法
存活率
Salivary gland neoplasms
Pathology
Combined modality therapy
Survival rate
