摘要
目的通过分析3例淋巴细胞性间质性肺炎(LIP),探讨LIP的病因、诊断及鉴别诊断。方法回顾性分析我院确诊的3例LIP患者的临床特点,并结合文献报道加以总结。结果(1)LIP常与自身免疫性疾病和免疫缺陷相关,起病缓慢,主要表现为进行性咳嗽和呼吸困难,双肺底听诊可闻及爆裂音,肺功能常表现为限制性通气功能障碍伴弥散功能受损。(2)高分辨率CT表现为边界不清的小叶中央性结节和胸膜下小结节、磨玻璃样影,支气管血管束增厚、小叶间隔增厚及囊状气腔。(3)支气管肺泡灌洗液中淋巴细胞增多。(4)病理表现为弥漫性肺间质致密淋巴细胞浸润,淋巴细胞呈多克隆性。结论特发性LIP罕见,若要确诊应进行全面检查以明确有无任何已知的病因或相关疾病。
Objective To explore the etiology, diagnosis and differential diagnosis of lymphocytic interstitial pneumonia（LIP）. Method The clinical,radiographical and histological characteristics of three cases of LIP diagnosed in Peking Union Medical College Hospital were analyzed, and the literature was reviewed. Results The precise cause of LIP was unknown. However, LIP was strongly associated with autoimmune diseases and immunedeficiency. Clinically, patients presented with chronic cough and progressive dyspnea. Pulmonary function tests showed restrictive venfilatory pattern. HRCT of chest revealed ground- glass attenuation, centrilobular nodules, subpleural small nodules, thickening of bronchovascular bundles, interlobular septal thickening and cystic dilated air spaces. Bronchoalveolar lavage showed an increase in lymphocytes. The key finding in histopathology was dense interstitial lymphoid infiltrate with a polyclonal pattern. Conclusion Idiopathic LIP is rare. Cases of LIP should be thoroughly investigated for any known causes and related disorders.
出处
《中华内科杂志》
CAS
CSCD
北大核心
2006年第4期293-297,共5页
Chinese Journal of Internal Medicine
关键词
肺疾病
间质性
肺纤维化
Lung diseases,interstitial
Pulmonary fibrosis
