摘要
背景:维生素A缺乏性疾病是一个世界性的儿童健康问题,中国西部及边远地区尤为严重,需要进行营养干预。目的:比较补充3种不同剂量强化维生素A饼干对3～6岁儿童维生素A营养状况的改善效果,探索预防维生素A缺乏性疾病的强化饼干的理想剂量。设计:随机对照观察。单位:重庆市卫生局卫生监督所、重庆医科大学公共卫生学院营养与食品卫生学教研室和重庆医科大学儿童医院儿童营养研究中心。对象:调查于2002-03/12完成,选择重庆市巴南区8个幼儿园的3～6岁儿童753名,监护人均知情同意。随机分为4组,即30%推荐摄入量组、100%推荐摄入量组、2万国际单位组及20万国际单位组。方法:①30%推荐摄入量组(177名)每日补充维生素A30%每日推荐摄入量(500IU)强化饼干1次。②100%推荐摄入量组(173名)每日补充维生素A100%每日推荐摄入量(1666IU)强化饼干1次。③2万国际单位组(209名)每周补充维生素A2万国际单位强化饼干1次。④20万国际单位组(194名)补充维生素A20万国际单位胶丸1次。所有儿童干预前及干预3个月时测定身高、体质量、血清视黄醇、前白蛋白、血红蛋白及视黄醇结合蛋白。30%推荐摄入量组中有87名儿童在补充9个月后再次复查以上指标。主要观察指标:①各组儿童干预前及干预3个月后维生素A缺乏性疾病检出率。②各组儿童干预前及干预3个月后血清视黄醇、血清前白蛋白、血清视黄醇结合蛋白、血红蛋白、身高和体质量。结果:因样本流失和检测技术的问题,复查仅得580名儿童的检测结果。①各组儿童维生素A缺乏性疾病检出率比较:补充3个月后,30%推荐摄入量组、100%推荐摄入量组、2万国际单位组及20万国际单位组儿童维生素A缺乏性疾病检出率均较治疗前显著下降[1.48%,1.42%,1.21%,2.16%;6.78%,6.54%,8.61%,8.25%(χ2=3.86～8.57,P<0.05～0.01)]。②各组儿童血清视黄醇、血�
BACKGROUND： Vitamin A deficiency disorders （VADD） is a healthy problem of children in the world, especially in the west of China and remote areas, and the nutritional intervention is needed.
OBJECTIVE： To compare the improved effects of biscuits fortified With three different doses of vitamin A on the vitamin A status in children aged 3-6 years and explore an ideal dose of vitamin A supplement for preventing VADD.
DESIGN： Randomized controlled observation.
SETTING： Health Surveillance Institute, Chongqing Municipal Health Bureau; Staff Room of Nutrition and Food Hygiene, College of Public Health, Chongqing University of Medical Sciences; Center for Children Nutrition, Children＇s Hospital, Chongqing University of Medical Sciences.
PARTICIPANTS： The investigation was done between March and December 2002. 753 children aged 3-6 years from 8 kindergartens in Banan district of Chongqing city were enrolled with the agreement of their guardians. They were divided randomly into 4 groups： 30% recommended intake group, 100% recommended intake group, 20 000 international unit （IU） and 200 000 IU groups.
METHODS： ① The biscuits fortified with 30% recommended intake of vitamin A （500 IU） were once given to people of the 30% recommended intake group （177 cases） every day. ②The biscuits fortified with 100% recommended intake of vitamin A （1666 IU） were once given to people of the 100% recommended intake group （173 cases） every day. ③The biscuits fortified with 20 000 IU of vitamin A were once given to people of the 20 000 IU group （209 cases） every week. ④The soft gelatin capsule with 200 000 IU of vitamin A were once given to people of the 200 000 IU group （194 cases）. Height, body mass, serum retinal, prealbumin, haematoglobin and retinal binding protein of all children were measured before intervention and after intervention for 3 months. Above indexes were rechecked after supplement for 9 months in 87 children of 30% recommended intake group
MAIN OUTCOME MEA
出处
《中国临床康复》
CSCD
北大核心
2006年第16期158-161,共4页
Chinese Journal of Clinical Rehabilitation
基金
瑞士SightandLife基金(2001-03)
重庆市教委科学基金(2001-19)
上海达能饼干食品有限公司资助(2002-03)~~
