摘要
目的观察曲美他嗪治疗冠状动脉粥样硬化性心脏病(CHD)心绞痛的临床疗效。方法冠心病心绞痛患者64例,随机分配到治疗组和对照组,两组在年龄、性别、心绞痛分型、合并病变及心功能分级分布均相仿。其中33例(治疗组)采用曲美他嗪20mgtid口服治疗,对照组31例不用曲美他嗪治疗,两组其他治疗冠心病心绞痛的方法、措施、药物均相同,观察两组心绞痛的发作频度、持续时间、硝酸甘油用量、心绞痛发作时心电图的心肌缺血情况等,并作疗效比较,2组疗程均为4周。结果两组均可显著降低心绞痛发作频率和硝酸甘油日耗量,并显著改善心电图ST-T,但是总的症状疗效、心电图疗效则治疗组优于对照组,治疗组心绞痛及心电图的总有效率分别为90.6%和71.9%,均显著高于对照组(54.8%和32.3%,P<0.05);治疗组在减少心绞痛症状、发作次数、持续时间、硝酸甘油用量、及改善心肌缺血的范围和程度等方面均显著优于对照组(P<0.05或P<0.01)。结论曲美他嗪治疗冠心病心绞痛疗效确切,在常规药物治疗的基础上,加用曲美他嗪可以进一步提高心绞痛的疗效。
Objective Observation curative effect of trimetazidine （TMZ） in treating coronary heart disease with Angina Pectoris. Methods Sixty-four cases of coronary heart disease with angina pectoris were randomly assigned to the study group （33 cases）and the contrast group （31 cases）. They were well matched for age,sex,anginal types,complications and cardiac functional grading. Among the study group 33 cases,TMZ were given to each 20 mg for 3 time every day orally; The contrast group weren＇t given each TMZ orally. The two groups otherwise treatment principle including drug and program were same. Observe and compare the frequency of angina pectoris; attack time and continuative time of angina pectofis; the daily consumption of nitroglycerin, improvement EST, NST, STmax and NT of electrocardiogram, between the study group and the contrast group.4 weeks as a therapy course in both 2 groups. Results Both the study group and the contrast group could not only reduce significantly the frequency of angina pectoris and the daily consumption of nitroglycerin,they also could result in remarkable improvement of NST,EST,STmax and NT. In treatment group, the total effective rate and electrocardiogram improvement rate were 90.6% and 71.9% respectively, it were higher than those in contrast group （54.8% and 32.3% respectively, all P〈 0.05）. Moreover, the decrease in attack time and continuative time of angina pectoris, reduction of nitroglycerin doses, improvment of myocardial ischemia degree, were superior in treatment group to those in contrast group （P〈0.05 or P〈0.01 ）. Conclusion It is definite that curative effect of trimetazidine treating CHD with angina pectoris, It may further increase cura- tive effect that Add trimetazidine treating ,when common dyugs treat coronary heart disease with angina pectoris.
出处
《中国心血管病研究》
CAS
2006年第4期267-269,共3页
Chinese Journal of Cardiovascular Research
关键词
曲美他嗪
冠状动脉疾病
心绞痛
Trimetazidine
Coronary disease
Angina pectofis
