摘要
目的探讨山楂叶提取物的抗氧化作用。方法选用Wistar雄性大鼠,在使用高脂饲料喂养的同时,灌喂高、中、低3种不同剂量的山楂叶提取物,4周后采血测定大鼠血清中超氧化物岐化酶(SOD)、谷胱苷肽过氧化物酶(GSH-Px)、血清LDL-C中维生素E、荧光物质的强度F和丙二醛(MDA)含量。结果灌喂山楂叶提取物高、中、低剂量的各组大鼠血清SOD与高脂对照组比较,差异无统计学意义(P>0.05),GSH-Px值均高于高脂对照组(P<0.05),各组LDL-C中维生素E含量与高脂对照组相比均有所增加(P<0.05)。山楂叶高、中剂量组荧光物质强度小于高脂对照组荧光物质强度(P<0.05)。山楂叶各组MDA值与高脂对照组相比差异无统计学意义(P>0.05)。结论山楂叶提取物能增加大鼠血清中GSH-Px活性,降低LDL-C中维生素E的消耗,减少荧光物质的产生,对低密度脂蛋白的氧化修饰有抑制作用,具有抗氧化作用。
Objective To study the effects that leaf of hawthorn restrain low-density lipoprotein C（LDL-C） oxidization. Methods This paper has chosen wister male rates as the object. While the rats were fed with high-fed stuff everyday, they were also fed with hawkthorn leaves, in high, medium and low doses respectively. After four weeks＇ observation, the levels of superoxide dismutase（SOD）, glutathione-Px（GSH-Px） mid Vitamin E, malonyl dialdehyde（MDA） and fluoreaceuce in LDL- C were studied. Results The levels of SOD in each groups showed no significantly difference（P〉 0.05）, The levels of GSH- Px in each leaf of hawthorn groups increased than that in high fat control group（P〈 0.05）. Vitamin E in high, medium and low doses groups showed significantly higher than that in high fat control group（ P 〈 0.05）. The levels of fluorescence in high doses grups, medium doses groups decreased compared with the level of high fat control group（P 〈 0.05）, There were no significantly difference in each leaf of hawthorn groups and high fat control group （P 〉 0.05）. Conclusion Leaf of hawthorn has the capacity of decreasing the content of fluorescence;decreasing the consume of Vitamin E in LDL-C; restraining LDL-C oxidization increase; and it has the capacity of anti-oxidation effects.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2006年第4期463-464,共2页
Chinese Journal of Public Health
关键词
山楂叶
抗氧化
低密度脂蛋白
leaf of hawthorn
anti-oxidization
low-density lipoprotein C（LDL-C）
