摘要
目的探讨重组人干扰素-γ(rhIFN-γ)联合维生素E对慢性乙型肝炎肝纤维化的影响。方法将50例慢性乙型肝炎患者随机分为对照组和治疗组,对照组仅给予保肝药,治疗组在对照组基础上加用rhIFN-γ及维生素E,疗程6个月。比较两组治疗前后ALT、AST及血清前胶原Ⅲ(PⅢP)、胶原Ⅳ(Ⅳ-C)、层连蛋白(LN)、透明质酸酶(HA)水平及治疗前后肝脏病理炎症积分,分析疗程结束时两组肝纤维化变化情况。结果两组ALT、AST均较治疗前有明显好转(P<0·05)。治疗组PⅢP、Ⅳ-C、HA、水平较治疗前显著降低(P<0·05),LN无明显的变化;对照组PIIIP、Ⅳ-C、HA、LN水平与治疗前相比,无显著的统计学意义。治疗组炎症、纤维化积分较治疗前有明显的下降(P<0·05),对照组无显著性改变。治疗后治疗组各期病理逆转率及总逆转率均优于对照组(P<0·05)。结论重组人干扰素γ联合维生素E对肝纤维化的发展具有一定的阻断作用,此疗法具有较好疗效、无明显副反应。
Objective To explore the impact of recombinant interferon - γ in combination with vitamin E on the fibrosis in chronic hepatitis B patients, Methods Fifty cases were randomly divided into observation group and control group each consisted of 25 cases. The patients in the control group were given liver protecting drug, and those in the observation group were given protecting drug plus rhIFN - γ and vitamin E for course of 6 months. The levels of ALT, AST, serum procollagen Ⅲ （PⅢP）, collagen Ⅳ （Ⅳ - C）, laminin （LN）, hyaluronidase （HA） in the two groups before and after Ireatmcnt were compared and the variations of liver fibrosis at the end of treatment were also analyzed. Results ALT and AST in the two groups were apparently improved （ P 〈 0. 05）. The level of plIIp, Ⅳ - C, and HA were significantly reduced （ P 〈 0.05）. No obvious change was observed in the level of LN. The levels of pIIIp, Ⅳ- C, LN and HA in the eontrol group showed no significant difference as compared with that before treatment. The degree of inflammation and score of fibrosis in observation group were obviously reduced as compared with that before treatment （ P 〈 0.05）. The pathological reverse rate and total reverse rate of observation groups at various phases in observation group were superior to that of control one （ P 〈 0.05）. Conclusion Recombinant interferon - γ in combination with vitamin E possessed certain blocking effect on the fibrosis in chronic hepatitis B patients. This therapy is effective with apparent side effect.
出处
《中国热带医学》
CAS
2006年第4期579-580,共2页
China Tropical Medicine
