摘要
目的探讨SARS后股骨头缺血坏死(ANFH)患者凝血功能。方法 SARS后股骨头坏死患者26例,空腹取静脉血,检测血小板膜糖蛋白CD31,CD61,CD62P,CD63,PAC-1和凝血4项指标: 血浆凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(Fbg)。并与 17例健康志愿者对照。结果 SARS后ANFH患者血小板膜糖蛋白CD31,CD61,CD62P,CD63,PAC-1 的表达均较正常人下降,差异有统计学意义(P<0．01),凝血4项PT,APTT,TT,Fbg与对照组比较差异无统计学意义(P>0．05)。结论 SARS患者出现股骨头坏死时血液可能是非高凝状态。
Objective To investigate the blood coagulation function in the patients with avascular necrosis of the femoral head after severe acute respiratory syndrome. Methods we measured respectively the expression of CD31, CD61, CD62P, CD63 and PAC-1 on platelet membrane by flowcytometry, and measured the plasma prothrombin time （ PT）, activated partial thromboplastin time （ APTT）, thrombin time （ TT）, and fibrinogen （Fbg） by blood clotting instrument in 26 patients with avascular necrosis of the femoral head after severe acute respiratory syndrome and in 17 healthy adults. Results The expression of CD31, CD61, CD62P, CD63 and PAC-1 on platelet membrane in 26 patients were all lower than those in 17 healthy adults （ P 〈 0. 01 ）. The levels of PT,APTT,TT,and Fbg in 26 patients were all in normal. There is no significant different （P 〉 0. 05） in those markers between patients and 17 healthy adults. Conclusions The blood may not be in hypercoagulable state in patients with avascular necrosis of the femoral head after SARS.
出处
《中华航海医学与高气压医学杂志》
CAS
CSCD
2006年第1期39-41,共3页
Chinese Journal of Nautical Medicine and Hyperbaric Medicine
