摘要
目的建立山地柏搽剂的制备及质量控制方法。方法采用薄层色谱法(TLC法)对该制剂中的山慈菇、地骨皮、黄柏进行定性鉴别,以薄层-紫外分光光度法测定样品中盐酸小檗碱的含量。结果薄层色谱中斑点清晰,易于识别,空白无干扰。盐酸小檗碱浓度线性范围为3.2～9.6μg/mL,r=0.9999,平均回收率为99.7%,RSD为0.84%。结论该方法简便、重现性、专属性、可靠性好,可用于该制剂的质量控制。
Objective To establish the preparation and quality control method of Shandibai liniment. Methods Pseudobulbus cremastrae seu pleiones, cortex lycii and cortex phellodendri chinensis were identified by TLC. The content of berberine hydrochloride was determined by TLC- UV. Results The TLC spots were fairly clear, easy to observe. And the blank showed no interference. There was a good linear relationship over the concentration range of 0. 080-0. 240 mg/mL for berberine hydrochloride, r =0. 999 9. The average recovery was 99.74% with RSD of 1.2%. Conclusion The method is simple, repeatitive, specific, and reliable. The quality control is easy to handle.
出处
《中国药业》
CAS
2006年第4期30-31,共2页
China Pharmaceuticals
关键词
山地柏搽剂
制备
质量控制
山慈菇
地骨皮
黄柏
Shandibai liniment
preparation
quality control
pseudobulbus cremastrae seu pleiones
cortex lycii
cortex phellodendri chinensis
