摘要
目的:研究肠易激综合征(IBS)患者乙状结肠推进性运动与胃肠肽胆囊收缩素(CCK)和胃动素(MTL)的关系,揭示CCK和MTL对IBS患者乙状结肠动力的调节作用。方法:符合罗马Ⅱ诊断标准的腹泻型(D-IBS)和便秘型(C-IBS)IBS患者各30例,年龄、性别匹配的健康志愿者15名,分别采用毛细管液体灌注测压法记录空腹状态下乙状结肠推进性高幅突发波的波幅及占记录时间百分比;同时采用放射免疫法测定所有研究对象血浆和乙状结肠黏膜CCK和MTL的含量。结果:D-IBS组乙状结肠推进性高幅突发波的波幅和持续时间显著高于C-IBS组和健康组(P<0.05),D-IBS组血浆MTL和CCK浓度显著高于C-IBS组和健康组(P<0.01),黏膜MTL含量显著高于C-IBS组和健康组(P<0.01)。IBS患者乙状结肠推进波的波幅和持续时间与血浆或黏膜CCK和MTL含量均呈正性相关(P<0.01)。结论:IBS患者乙状结肠推进性运动与血浆CCK、黏膜和血浆MTL含量密切相关。
Objective To investigate the relationship between the sigmoid colon propagating contractions and the gut hormones cholecystokinin（CCK） and motilin（MTL） in the patients with irritable bowel syndrome（IBS）, and to reveal the gut hormones＇ modulation to the sigmoid colon motility. Methods Thirty diarrea-predominant IBS patients（D-IBS）, 30 constipation-predominant IBS patients（C-IBS） and 15 sex/age matched healthy volunteers were enrolled in the study. The high amplitude propagating waves and their time percentages of the sigmoid colon were measured by means of a liquid-perfused capillary tube connected to a computer. Meanwhile, the concentrations of CCK, MTL in the plasma and the sigmoid colon mucosa were tested by means of immunoassay technology. Results The D-IBS group had higher amplitude of the sigmoid colon propagating waves and their time percentage than that of the C-IBS group and the control group（P〈0.05）. The plasmal concentrations of CCK and MTL in the D-IBS group were higher than those in the C-IBS group and the control group（P〈0.01）, and so did the mucosal concentrations of MTL（P〈0.01）. The amplitude of the propagating waves and their time percentages were positively correlated with plasmal or mucosal CCK, MTL concentrations（P〈0.05）. Conclusions The sigmoid colon propagating motility in IBS is closely correlated with plasmal CCK and MTL and mucosal MTL concentrations.
出处
《诊断学理论与实践》
2006年第1期24-26,共3页
Journal of Diagnostics Concepts & Practice
基金
广西留学回国人员基金(桂科回9920013)
广西自然科学基金(桂科自0339029)
