摘要
目的探讨骨桥蛋白(OPN)在肝细胞癌(肝癌)组织中的表达与血管生成的关系。方法采用免疫组化法检测64例肝癌组织、10例肝硬化组织及10例正常组织中的OPN,分析其与肝癌临床病理特征和微血管密度(MVD)的关系。结果OPN在肝癌组织的表达明显高于肝硬化组织及正常组织(P<0.05),OPN和肝癌的早期复发转移有关(P<0.01),OPN的表达和MVD呈正相关(r=0.321,P<0.01)。结论OPN在肝癌组织中呈高表达与早期复发转移相关;OPN可能参与了肿瘤的血管生成。
Objective： To study the expressions of osteopontin （OPN） in hepatocellular carcinoma（HCC） and angiogenesis. Methods： Expressions of OPN was detected in 64 tumor tissues, 10 hepatic cirrhosis tissues and 10 normal hepatic tissues by immunohistochemistry method. Correlation between the expressions and clinicopathological features, MVD was analyzed. Results： The expression of OPN was higher in HCC than that in hepatic cirrhosis and normal tissues （ P〈0. 05）, and related to early recurrence and metastasis （ P〈0. 01） ; A positive correlation between OPN expression and MVD was found in HCC（ r = 0. 321, P 〈0.01）. Conclusion ： The high expression of OPN in HCC relat to early recurrence and metastasis,and OPN maybe participated in carcinoma angiogenesis.
出处
《山东医药》
CAS
北大核心
2006年第9期3-5,共3页
Shandong Medical Journal
