摘要
目的探讨不同剂量异丙酚复合硬膜外阻滞对单肺通气（OLV）患者氧合与分流的影响。方法择期食管癌手术患者40例在T6-7为穿刺点常规置管硬膜外麻醉后，随机分为Ⅰ组（n=20）静脉输注异丙酚5mg·kg^-1·h^-1；Ⅱ组（n=20）输注异丙酚10mg·kg^-1·h^-1，在开胸前及开胸后OLV 30min、60min分别取动脉血样即时作血气分析。结果OLV3 0min时，Ⅰ、Ⅱ组肺内分流率（Qs／Qt）分别为（11．35±3．6）和（15．6±5．41）；PaO2分别为（36．12±10．23）和（31．05±9．36）。0LV 60min时Ⅰ、Ⅱ组Qs／Qt分别为（13．9±3．7）和（18．5±2．1）；PaO2分别为（34．87±15．42）和（26．97±11．35），两组比较差异有统计学意义（P〈0．05）。结论5mg·kg^-1·h^-1异丙酚输注复合硬膜外阻滞对肺内分流及氧合影响小。
Objective To study the effect of different dose of propofol compounding with epidural anesthesia on oxygenation and shunt fraction during one-lung ventilation（OVL）. Methods Forty patients with esophageal carcinoma undergoing thoracotomy were randomly divided into group Ⅰ and Ⅱ . After placing epidural tube at T6-7 for epidural anesthesia,the patients group Ⅰ were received propofol 5mg·kg^-1·h^-1 and 10mg·kg^-1·h^-1 in group Ⅱ. Taking the blood sample from arter for blood-gases mea.su.rement at beginning of operation,30min after OVL and 60min after OVL. Results At 30min after OVL, the shunt fraction（Qs/Qt） value of group Ⅰ and Ⅱ was （11.35 ± 3.6） and （ 15.6 ± 5.41 ） ; PaO2 was （36.12 ± 10.23） and （31.05 ± 9.36）. At 60min,the Qs/Qt was （ 13.9 ± 3. 7 ） and （ 18.5 ± 2.1 ） ; PaO2 was （34.87 ± 15.42 ） and （26.97 ± 11.35）. There was significantly difference between two groups（P 〈 0.05 ）. Conclusion The effect of propofol compounding with epidural anesthesia on oxygenation and shunt fraction during one-lung ventilation is smaller at 5mg·kg^-1·h^-1.
出处
《中国基层医药》
CAS
2006年第2期303-304,共2页
Chinese Journal of Primary Medicine and Pharmacy
