摘要
为了探讨儿童铅中毒的诊断标准，作者选择１３２名婴儿，以其脐血铅水平作为铅暴露示标，３月龄时在蓓蕾（Ｂａｙｌｅｙ）婴儿发育量表上的精神发育指数（ＭＤＩ）和心理运动发育指数（ＰＤＩ）为效应示标，研究铅对婴儿神经发育的影响。结果血铅≥０．４８μｍｏｌ／Ｌ的婴儿其ＭＤＩ和ＰＤＩ均明显落后于血铅＜０．４８μｍｏｌ／Ｌ者。若分别以血铅为０．７２、０．４８和０．２４μｍｏｌ／Ｌ为分界线，将所有婴儿分为高铅组和相对低铅组，发现随着分界线的下移，两组间ＭＤＩ和ＰＤＩ的差别渐趋缩小，当分界线为０．２４μｍｏｌ／Ｌ时，高低铅组间ＭＤＩ和ＰＤＩ的统计学差异不复存在。据此，作者建议，我国宜采纳血铅≥０．４８μｍｏｌ／Ｌ作为儿童铅中毒的诊断标准。
Onehundredandthirty-twobabieswereselectedandtheirumbilicalbloodleadlevelweredeterminedasamarkertoreflecttheirexposure,tostudythediagnosticcriteriaforleadpoison-inginyoungchildren.And,mentaldevelopmentindex(MDI)andpsychomotordevelopmentindex(PDI)ofthree-monthbabiesinBayleyscalesofinfantdevelopmentwereusedasefectiveindicatorstostudyefectsofleadontheirdevelopment.ResultsindicatedthatbothMDIandPDIininfantswithbloodleadlevelsofgreaterthanorequalto0.48μmol/Lwereobviouslylowerthanthosewithlesthan0.48μmol/L.Althechildrenweredividedintotwogroups(high-blood-leadandlow-blood-lead)accordingtothecut-ofvaluesforbloodleadlevelof0.72,0.48,and0.24μmol/L,re-spectively,andthediferenceinMDIandPDIbetwenthetwogroupsdecreasedgradualywiththecut-ofvalueshifteddown,andtherewasnodiferenceinthembetweenthetwogroupswhenthecut-ofpointloweringdownto0.24μmol/L.Therefore,theauthorsrecommendedthatalevelof0.48μmol/Lofbloodleadbeusedasdiagnosticcriteriaforleadpoisoninginyoungchildren.
出处
《中华预防医学杂志》
CAS
CSCD
北大核心
1996年第2期68-70,共3页
Chinese Journal of Preventive Medicine
基金
国家自然科学青年基金
上海市科技发展基金
