摘要
目的:研究维库溴铵对老年病人的肌松效应。方法:94例病人(32-97岁)按年龄分为4组(A,B,C,D),A组为对照组B组60-69岁,C组70-89岁,D组90-97岁,均于全麻诱导时静注维库溴铵0．12 mg·kg-1,并进行神经肌肉阻滞监测。结果:(1)A组病人维库溴铵起效时间明显比其余3组长(P<0．01),D组病人肌松起效时间快于B组和C组(P<0．01)。(2)A组病人T1为零时间明显比其余3组病人长(P<0．01),B、C组T1为零时间无差异(P>0．05),D组病人则短于B组和C组(P<0．01)。(3)A组和B组首次给药后T110％恢复时间和停药后T125％恢复时间显著快于C组和D组(P<0．01)。(4)不同年龄组维库溴铵用量随年龄增加而减少(P<0．01)。结论:随着年龄的增长,高龄病人维库溴铵起效时间,达最大效能时间增快、维持用量减少和肌松持续时间延长。
Objectives. To study the neuromuscular block pharmacodynamics of vecuronium bromide in aged patients. Method： Ninety-four patients were divided into 4 age groups. Group A was controlled group, group B 60 - 69 years, group C 70 - 89 years and group D was 90 -97 years old. After general anesthesia was start, vecuronium bromid was injected intravenously, the dose of vecuronium bromide was 0.12 mg·kg^-1, and the neuromuscular block was monitor. Result： （1） The onset time of the effect of vecuronium bromide was significantly longer in group A than those in other three groups （P 〈0.01 ） and was shorter in group D than that in group B and C （ P 〈 0.01 ）. （2） The zero time of T1 in group A was longer than the orther three groups obviously （ P 〈 0.01 ）, the zero time of T1 in group B and group C had no difference （ P 〉 0.05 ） , and the zero time of T1 in group D was shorter than group B and C （ P 〈 0.01 ）. （3）The recovered time of T1 10% after the first injection and there recovered time of T1 25% after the injection stoped in group A and B were faster than group C and D obviously. （4） The dose of vecuronium bromide in different age groups were decreased by increased ages. Conclusion： The begining of effective time of vecurunium bromide is faster and less amounts of vecuronium bromide is needed and the dose of vecuronium bromide is decreased when it is given to aged patients.
出处
《中国药师》
CAS
2006年第3期258-259,共2页
China Pharmacist
