摘要
目的探讨细胞凋亡和细胞增殖在成釉细胞瘤发生发展中的作用。方法应用免疫组织化学SP方法检测27例良性成釉细胞瘤和17例恶性成釉细胞瘤中Bc l-2、c-myc和PCNA的表达。结果c-myc和增殖细胞核抗原(PCNA)在恶性成釉细胞瘤中的表达显著高于良性成釉细胞瘤(P<0.01)。Bc l-2的表达在良、恶性之间无显著性差异(P>0.05)。c-myc和PCNA表达之间呈显著的正相关关系(P<0.01)。结论Bc l-2和c-myc可能与成釉细胞瘤的发生发展有关,c-myc参与细胞的恶性转化,c-myc和PCNA可作为鉴别良恶性成釉细胞瘤的参考指标。
Objective To investigate the effect of apoptosis and proliferation in ameloblastoma. Methods The expression of Bcl - 2 , c - myc and PCNA was observed in 27 cases of benign ameloblastoma and 17 cases of malignant ameloblastoma using SP immunohistochemical staining. Resuits The expression of c - myc and PCNA in malignant ameloblatoma was significantly higher than that in benign ameloblastoma overexpression （ P 〈 0.01 ） . There existed no difference of the expression of Bcl - 2 between benign and malignant ameloblastoma （ P 〉 0 . 05 ）. The expression of c - myc and PCNA showed a significantly positive correlation （ P 〈 0 . 01 ）. Conclusion Bcl - 2 and c - myc may be connected with the initiation and progression of ameloblastoma, c - myc may be related to cell malignant transformation, c -myc and PCNA could act as markers in differentiation benign from malignant ameloblastoma .
出处
《医药论坛杂志》
2006年第1期10-12,共3页
Journal of Medical Forum
