摘要
肾小管上皮细胞转分化(EMT)过程广泛存在于胚胎发生和肾纤维化过程中,其调节是一个复杂有序的过程,受多种细胞因子和细胞外基质的调节。促纤维化细胞因子如TGF-β1具有诱导EMT的作用,而抗纤维化细胞因子如骨形成蛋白-7(BMP-7)和肝细胞生长因子(HGF)能抑制纤维化过程。
Tubular epithelial myofibroblast transdifferentiation （EMT） is an important event during progressive renal tubulointerstitial fibrosis. It should be stressed that the phenomena of EMT is exten- sive in embryonic development and renal fibrosis. Tubular EMT is highly regulated process, it is regulated by numerous cytokines and extracellular cues. Of the many factors that regulate EMT in different ways, transforming growth factor-β1 （TGF-β1） is the most potent inducer that is capable of initiating and completing the entire EMT course, whereas hepatocyte growth factor （HGF） and bone morphogenetic protein-7 （BMP-7） act as EMT inhibitors. This article attempts to provide a comprehensive review of recent advances on understanding molecular mechanism, and therapeutic intervention of EMT in chronic renal tubulointerstitial fibrosis.
出处
《国际病理科学与临床杂志》
CAS
2006年第1期63-66,共4页
Journal of International Pathology and Clinical Medicine
基金
国家自然科学基金(30371834
30500687)
上海市高等学校科学技术发展基金(OZCK10)
关键词
肾小管上皮细胞
转分化
肾问质纤维化
renal tubular epithelial cell
transdifferentiation
renal tubulointerstitial fibrosis
