摘要
采用氢气清除法测定胃粘膜血流量(gastric mucosal blood flow,GMBF),以及用利多卡因消除十二指肠传入信息的技术,观察传入信息在十二指肠灌注高渗盐溶液对外源性五肽胃泌素(pentagastrin,G_5)引起的胃酸分泌和 GMBF 抑制效应中的作用。结果表明:(1)静脉灌注 G_5引起胃酸分泌和 GMBF 增加;(2)十二指肠灌注高渗盐溶液可使 G_5激发的胃酸分泌明显减少,而 GMBF 不再增高;(3)使用利多卡因后,在十二指肠灌注高渗盐溶液对胃酸分泌和 GMBF 的抑制性影响消除。这提示十二指肠传入信息不仅可调节生理性胃酸分泌,而且在十二指肠内灌注高渗盐溶液对 G_5刺激胃酸分泌和 GMBF 的抑制性效应中亦有作用。
By hydrogen gas clearance technique to measure gastric mucosal blood flow(GMBF) and infusion of lidocaine to remove the effects of duodenal afferent messages,we studied the role of duodenal afferent messages in the inhibitory effects induced by duodenal infusion of hyperosmotic solu- tion on gastric acid output(AGO)and GMBF response to intravenous perfusion pentagastrin(G_5). The results were as follows:(1)intravenous administration of G_5(50 μg/kg·45 min)promoted GAO and increased GMBF significantly;(2)duodenal infusion of hyperosmotic solution would signifi- cantly inhibit the GAO and GMBF response to i.v G_5,but GAO was still higher than that of basal; (3)the inhibitory effects of duodenal infusion of hyperosmotic solution On GAO and GMBF were com- pletely abolished by duodenal infusion of lidocaine.The results showed that duodenal afferent messages play a role on the regulation in physiological GAO and also in the inhibitory effects of GAO and GMBF stimulated by G_5 during duodenal infusion of hyperosmotic solution.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
1996年第1期13-16,共4页
Journal of Nanjing Medical University(Natural Sciences)
关键词
胃酸分泌量
胃粘膜血流量
十二指肠
传入神经
gastric acid output
gastric mucosal blood flow(GMBF)
pentagastrin
afferent message
rat
