摘要
风湿性疾病患者血清铜锌超氧化物歧化酶测定于孟学，史立，张春芳，程蓉董怡，李培峰（中国医学科学院中国协和医科大学北京协和医院，北京１００７３０）关键词风湿病，超氧化物歧化酶类中图号Ｒ５９３．２１Ｑ５５４．９超氧化物歧化酶（ＳＯＤ）是一种重要的氧自由基清...
Abstract Superoxide anion plays an important parthreactive oxygen speciES(ROS).In or-der to explore its effect on the pathogenesis of rheumatic diseases,authors had determinedCuZn-SOD contents of sera in l 32 subjects involving the patients of rheumatic diseases(SLE,RA,etc),non-rheumatic diseases and normal controls by using enzyme linked im-munosorbent assay(ELISA).The results showed the followings:CuZn-SOD contents of 27normal subjects :98.80±20.74ng/ml;that of 27 non-rheumatic diseases cases:72.24±16.60ng/m1(x±s);of 22 SLE cases:56.56±19.27ng/ml;of 27 RA cases:61.56±20.53ng/m1;of 29 other rheumatic diseases cases:68.97±17.79ng/ml.Sta-tistical test was made:both CuZn-SOD contents of rheumatic disease and non-rheumatic dis-ease were lower than that of normal subjects with more significant difference(P<0.001);compared with that of non-rheumatic diseases patients,SLE cases had significant difference(P<0.01);RA cases had significant difference(P<0.05);other cases of rheumatic diseaseshad no statistical differrence(P>0. 05).Above results suggest that superoxide anion is anon-specific inflammatory mediator which contributes to disorders with iriflammatory dam-ages(rheumatic or non-rheumatic diseases),where CuZn-SOD content tested was obviouslylower than normal suUects;among the rheumatic disease patients,CuZn-SOD contents ofthe sera of SLE patients were the lowest because of its more autoimmune antibody,more severe inflammatory and immunological reaction. This work laid the theoretical and experi-mental foundation for the clinical application of exogenous CuZn-SOD in the treatment ofrheumatic diseases,Combined use of CuZn-SOD scavengers may get better result because ofthe complexibility of ROS inflammatory mechanism.
出处
《中国医学科学院学报》
CAS
CSCD
北大核心
1996年第1期66-69,共4页
Acta Academiae Medicinae Sinicae
