摘要
目的探讨早期应用大剂量纳洛酮治疗重型颅脑损伤的临床疗效。方法随机选取150例重型颅脑损伤病人作为治疗组，采用盐酸纳洛酮每天0．1～0．2mg／kg，持续静脉点滴7天。对照组不使用盐酸纳洛酮。比较两组病人治疗7天后GCS评分及3个月后GOS评分。结果治疗前两组病人年龄、GCS评分具有可比性（P〉0．05）。治疗7天后两组病人GCS评分，差异有统计学意义（P〈0．05）。随访3个月后GOS评分．差异亦有统计学意义（P〈0．05）。结论早期大剂量使用纳洛酮治疗重型颅脑损伤病人，可明显改善病人的预后．疗效确切。
To explore the therapeutic effect of large dose of naloxone hydrochloride in patients with severe cranioeerebral injury. Methods Randomly chose 150 patients with severe cranioeerebral injury as intervention group. Naloxone hydrochloride was infused intravenously at the dose of 0. 1-0. 2mg/kg/per day for 7 days. No naloxone hydrochloride was given to control group. The scores of GCS after 7 days and GOS after 3 months of the two groups were compared. Results The age and GCS scores of the two groups before treatment were comparable （P〉0. 05）. There was significant difference in GCS scores after 7 days of treatment between the two groups （P〈0. 0S）and extremely significant difference in GOS scores after 3 months of treatment （P 〈 0. 01 ）. Conclusion Early administration of large dose of naloxone hydrochloride can achieve a favorable effect and considerably ameliorate prognosis for patients with severe eraniocerebral injury.
出处
《西部医学》
2006年第2期179-180,共2页
Medical Journal of West China
