摘要
目的了解肝细胞肝癌组织中生长抑素受体(SSTR)亚型1-3基因的表达情况。方法采用RT-PCR法检测了48例肝细胞肝癌患者癌组织和癌旁组织中生长抑素受体亚型1-3mRNA的表达。结果48例肝细胞肝癌患者的癌组织和癌旁组织中SSTR1mRNA表达的阳性率分别为18.7%(9/48)和31.3%(16/48);SSTR2mRNA表达的阳性率分别为91.6%(44/48)和93.7%(45/48);SSTR3mRNA表达的阳性率分别为20.8%(11/48)和50.0%(24/48)。结论肝细胞肝癌组织中大多数有一种以上生长抑素受体亚型的表达,其中SSTR2为主要表达亚型。
Objective： To investigate SSTR subtypes 1-3mRNA expression in tissue of primary hepatic carcinoma. Methods： The expression of SSTR subtypes 1-3mRNA in the tumor tissues of hepatic carcinoma and the adjacent tissues of cancer in 48 patients with primary hepatic carcinoma was examined by RT-PCR. Results ; The positive rate of expression of SSTR 1 mRNA was 18.7 % （9/48） in the tissues of hepatic carcinoma and 31.3% （16/48） in the adjacent tissues of cancers. The positive rate of expression of SSTR2 mRNA was 91.6% （44/48） and 93. 7% （45/48） in the tissue of hepatic carcinoma and the adjacent tissue of cancer respectively. The positive rate of expression of SSTR3 mRNA was 20. 8% （11/48） and 50% （24/48）respectively. Conclusion： There is more than one SSTR subtype genes expression in tumor tissues of primary hepatic carcinoma, and SSTR2 is the main subtype for expression in tissues of primary hepatic carcinoma.
出处
《陕西医学杂志》
CAS
北大核心
2006年第3期294-296,共3页
Shaanxi Medical Journal
关键词
肝肿瘤/免疫学
生长抑素受体
基因表达调控
mRNA
Liver Neoplasms/immunology Somatostation Receptor Subtypes Gene Expression Regulation, mRNA
