摘要
目的探讨多发性骨髓瘤患者早期死亡的临床危险因素。方法回顾性分析18例早期死亡(6个月内)的初治多发性骨髓瘤患者的临床资料。单因素和LOGISTIC回归多因素分析影响多发性骨髓瘤患者早期死亡的临床危险因素。结果单因素分析发现,年龄、血乳酸脱氢酶(LDH)水平、血白蛋白水平、血肌酐(CR)水平、血Β2微球蛋白(Β2"MG)水平和是否合并有淀粉样变是早期死亡的危险因素;而多因素分析确定只有血白蛋白水平、血CR水平、血Β2"MG水平及是否合并有淀粉样变是早期死亡的危险因素。结论低白蛋白血症、肾功能不全、高血Β2"MG水平、合并有淀粉样变的多发性骨髓瘤患者是早期死亡的高危患者。
Objective To identify the clinical factors predicting early death of muhiple myeloma patients. Methods We analyzed 18 patients with recently diagnosed multiple myeloma died within 6 months （early death）. The clinical factors of early death patients at the diagnosis were analyzed by univariate analysis and logistic regression multivariate analysis. Results Univariate analysis found that age, serum lactic dehydrogenase （LDH） level, serum albumin level, serum creatinine level, serum β2-microglobulin （β2-MG） level, with amyloidosis complaint were predict factors for early death of multiple myeloma patients. But multivariate analysis showed that only serum albumin level, serum creatinine level, serum β2-MG level, with amyloidosis complaint were predict factors. Conclusions The patients of recent diagnosed multiple myeloma with low serum albumin level, high serum creatinine level, high β2-MG level and amyloidosis are at high risk of early death.
出处
《北京医学》
CAS
2006年第3期132-134,共3页
Beijing Medical Journal
