摘要
目的观察κ阿片受体激动剂U50488H对大鼠血压的影响并探讨其作用机制。方法监测正常大鼠心率(HR)、动脉压(ABP)、左心室内压(LVP)及左室的收缩(+dp/dtm ax)和舒张功能(-dp/dtm ax)等血流动力学指标和尿量的变化;分离正常大鼠腹主动脉,测定血管张力的变化。结果在整体水平,静脉注射U50488H可降低大鼠HR、ABP、LVP及±dp/dtm ax;而且可增加大鼠的尿量。在离体水平,U50488H对大鼠腹主动脉具有明显的剂量依赖性舒张作用;以上效应均可被选择性κ阿片受体阻断剂nor-BNI所阻断。结论激动κ阿片受体可引起降压作用,抑制心肌收缩力、舒张血管和利尿是其降压的主要机制。
Aim To investigate the effects of US0488H,a selective κ-opioid receptor agonist, on the blood pressure in the rats and explore their mechanisms. Methods Heart rate （HR）, arterial blood pressure （ ABP ）, left ventricular pressure （ LVP ）, contractive function （ ＋ dp/dtmax ） and diastolic function （ -dp/dtmax ） were examined in rats. Physiological experimental technique was used to collect urine and to determine the volume of urine output; isolated artery perfusion technique was used to investigate the direct action of US0488H on abdominal aorta of rats. Results HR, ABP, LVP and ＋ dp/dtmax in rats were decreased with the administration of U50488H; the urine volume increased significantly with the administration of U50488H. U50488H induced a dose-dependent vasodilation in the aortic artery. These effects of U50488H were totally abolished by nor-BNI, a selective κ-opioid receptor antagonist. Conclusion Stimulation of κ-opioid receptor with U50488H depresses the blood pressure mainly by reducing the strength of cardiac muscle, enhancing the urine volume and relaxing the vessel.
出处
《中国药理学通报》
CAS
CSCD
北大核心
2006年第3期284-287,共4页
Chinese Pharmacological Bulletin
基金
国家自然科学基金面上资助项目(No30370580)
全军医药卫生科研基金军队"十五"计划面上资助项目(No01MB129)
第四军医大学创新工程重点资助项目(NoCX01F001)
关键词
Κ阿片受体
血压
腹主动脉
利尿
κ-opioid receptor
blood pressure
ab-dominal aorta
diuresis
