摘要
目的:了解硝普钠临床治疗的有效性和安全性。方法:对近10年(1995￣2004年)在我院住院时曾接受硝普钠治疗的3894例患者进行回顾性调查,调查内容包括药物使用剂量,药物使用时间,药物有效率及毒副反应发生率等情况。结果:所有调查对象中连续给药时间最短为0.5h,最长为368h,平均125.5±24.2h。给药剂量最小为0.2μg/(kg.m in),最大为9.8μg/(kg.m in),平均3.1±1.9μg/(kg.m in)。连续给药总量最小2.5m g,最大2050m g,平均210±26.7m g。3894例病例中治疗有效3521例,有效率90.4%;无效278例,占7.1%;死亡95例,占2.4%,其中因药物中毒引起的死亡1例,占总病例数的0.02%。药物常见副反应发生率13.7%,低血压发生率10.2%,药物反跳发生率3.2%,耐药性发生率0.3%,上述副反应通过适当的保护措施就可预防。结论硝普钠临床治疗有效性及安全性高,严重的毒副反应发生率极低,低血压等常见副反应发生率较高但可控制。
Objective： To investigate the efficacy and safety of clinical use of sodium nitroprusside. Methods： The data of 3894 hospitalized patients who had ever been treated with sodium nitroprusside between 1995 and 2004 in our hospital were retrospectively collected. The therapeutic dose, time of therapy, effective rate and side effect were assessed. Results： The minimum time of continuous infusion with sodium nitroprusside was 0.5hour, the maximum 368 hour, average 125.5 ± 24.2 hours. The minimum dose of sodium nitroprusside infusion was 0.2 μg/（ kg·min ） , the maximum 9.8 μg/（ kg·min ）, average 3.1 ± 1.9 μ g/（ kg·min ）. The minimum dose of continuous infusion was 2.5mg, the maximum 2050mg, average 210 ± 26.7mg. Among the 3894 patients, 3524 cases were effective, accounting for 90.4%; 278 cases were ineffective, accounting for 7.1%; 95 cases were death, amounting 2.4%, among which the cases caused by ssodium nitroprusside toxicity accounted for 0.02%. The total incidence of caused by sodium sodium nitroprusside toxicity accounted for 0.02%. The total incidence of common side effect was 13.7 %. The incidence of hypotention, rebound and tolerance were 10.2 %, 3.2% ,and 0.3 % respectively, which might be prevented by some protective measures. Conclusion： It is effective and safe for patients to undergo treatment with sodium nitroprusside. Sever toxicity is rare. Although the common side effect is frequent, but it can be controlled.
出处
《重庆医科大学学报》
CAS
CSCD
2006年第1期110-112,共3页
Journal of Chongqing Medical University
关键词
硝普钠
有效性
安全性
Sodium nitroprusside
Efficacy
Safety
