摘要
目的了解大肠埃希菌和肺炎克雷伯菌产ESBLs的情况，观察其耐药性，指导临床医生合理使用抗生素。方法ESBLs检测采用仪器测试和确诊试验，药敏试验采用VITEK AMS仪器测试和纸片扩散法联合检测其对22种抗生素的耐药性。结果大肠埃希菌和肺炎克雷伯菌产ESBLs的阳性率分别为43．7％和34．4％，自动化检测法低于确诊试验。产ESBLs的菌株对头孢菌素类呈现高度的耐药，对喹诺酮类、庆大霉素呈明显耐药，对哌拉西林／他唑巴坦，头孢哌酮，舒巴坦、阿米卡星和头孢西丁的耐药率较低，对亚胺培南呈高度敏感。结论医院产ESBLs的菌株阳性率较高，应开展ESBLs检测，防止ESBLs的产生与传播。
Objective To evaluate the ESBLs production and drug resistance of Escherichia coli and KlebsieUa pneumoniae, to direct reasonable usage of antibiotics in clinical practice. Methods equipment test and final diagnosis test were applied into detecting of ESBLs. Drug susceptibility to 22 kinds of antibiotics was detected by VITEK AMS equipment and slip diffusion method. Results Positive rate of ESBLs in Escherichia coli and Klebsiella pneumoniae were 43.7% and 34.4%, respectively. ESBLs positive strains were highly resistance to cephaiosporins; also resistance to Quinolones and gentamycin; not resistance to piperacillin/sulbactam, cefoperazone/sulbactam, amikacin and cefoxitin, and highly sensitive to imipenem. Conclusions ESBLs was highly expressed in nosocomial strains of bacterium. Test for ESBLs should be recommended in order to prevent the genesis and wide spread of ESBLs.
出处
《世界感染杂志》
2006年第1期61-63,共3页
World Journal of Infection
关键词
ESBLS
药物敏感试验
抗生素
耐药率
ESBLs
drug susceptibility test
antibiotics
drug resistance rate
