摘要
目的探讨二甲双胍对2型糖尿病患者血浆总同型半胱氨酸水平的影响.方法采用高效液相荧光检测的方法测定30例健康对照者、30例2型糖尿病患者及服二甲双胍(0.75～1.00 g/天)治疗3个月后的糖尿病患者血浆总同型半胱氨酸的水平.结果 2型糖尿病患者血浆总同型半胱氨酸水平(14.1±5.7 μmol/L)高于对照组(9.5±3.4 μmol/L, P<0.01),并且总同型半胱氨酸水平与年龄、体质指数、空腹血糖和空腹胰岛素明显正相关(P<0.05),与胰岛素敏感指数呈负相关.二甲双胍治疗3个月后,血浆总同型半胱氨酸水平(11.6±4.7 μmol/L)比治疗前降低(P<0.05).结论 2型糖尿病患者血浆总同型半胱氨酸水平增高,二甲双胍治疗后可降低血浆总同型半胱氨酸水平.
Aim To investigate the effects of mefformin on the levels of plasma total homocysteine （tHey） in patients with type 2 diabetes mellitus （DM）. Methods The levels of they was determined by high performance liquid chromatography （HPLC） with fluorescence detection in 30 untreated type 2 DM cases and 30 healthy cases as control. 30 DM patients were treated with metformin for three months （0.75～1.00g/d）, after the treatment, tHey was detected again. Results tHey was significantly higher in type 2 DM compared to controls （ 14.1 ± 5.7μmol/L vs 9.5 ± 3.4μmol/L, P 〈 0.01 ）, and was correlatedwithage, BMI, FBG, FINS （P〈0.05）, negative correhted with ISI （P〈0.05）. Following three months treatment with metformin, tHcy levels was significantly decreased （11.6±4.7μmol/L, P〈0.05）. Conclusion The levels of tHcy increase in type 2 DM. After treating with meffonnin, the levels of tHey decrease.
出处
《中国动脉硬化杂志》
CAS
CSCD
2005年第5期636-638,共3页
Chinese Journal of Arteriosclerosis
