摘要
目的:探讨根除幽门螺杆菌(HP)治疗胃食管反流病的效果。方法:选取经胃镜诊断为胃食管反流病(Ⅰ～Ⅱ级)并经快速尿素酶测定伴有HP感染的患者53例。口服丽珠得乐1粒每日4次加克拉霉素0.25g每日2次加甲硝唑0.4g每日2次,连续14天根除HP。分别在根除HP前及根除后1个月,对患者进行24小时食管内pH值监测、食管内压力测定及快速尿素酶试验检测HP。结果:40例患者完成了研究,9例患者症状消失,31例患者仍有食管炎症状。28例患者的食管炎症状评分降低,而12例患者无变化(P<0.05)。根除HP后1个月,食管pH值小于4的时间占总时间的百分比,在22例患者有增加,18例患者有减少。患者食管24小时pH值的其他参数和食管下端括约肌的平均静息压力无明显变化。结论:胃食管反流病患者在根除HP后1个月,其胃食管反流没有得到有效控制,但一些与反流相关的症状却有明显改善。
Objective： To investigate the effect of Helicobacter pylori （tiP） eradication on gastroesophageal reflux disease （GERD）. Methods： 53 patients with HP infection and GERD （gradeⅠ or Ⅱ ） were enrolled in this study. 24 h intra-esophageal pH recording and esophageal nanometry were performed before and 1 month after HP eradication, which was achieved using Lizhu Dele 1 tablet qid ＋ Clarithromycin 0.25g bid ＋ Metronidazole 0.4g bid for 14 days. Results： 40 patients （16 men and 24 women, mean age 52 years） completed the study. The symptoms persisted in 31 patients and disappeared in 9 patients. Esophagitis score decreased in 28 patients, and did not change in 12 patients （P〈0.05）. One month after the treatment, the percentage of total time esophageal pH lower than 4 increased in 22 patients and decreased in 18 patients. But other parameters of the 24h esophageal pH recording and mean lower esophageal sphincter resting pressure did not change significantly （P〉0.05）. Conclusion： HP eradication cannot control gastroescophageal acid reflux in GERD patients 1 month after eradication, but it significantly improves some reflux-related symptoms.
出处
《现代医药卫生》
2006年第5期634-635,共2页
Journal of Modern Medicine & Health
关键词
胃食管反流病
幽门螺杆菌
药物治疗
Gastroesophageal reflux disease
Helicobacter pylori
Medical treatment
