摘要
目的通过在尿道外括约肌(EUS)局部使用高选择性神经肌接头阻滞剂α-金环蛇毒,以明确EUS松弛后能否改善雄性脊髓损伤(SCI)大鼠的排尿功能。方法分别在正常和SCI大鼠的EUS局部注射α-金环蛇毒100μg/kg,同时比较用药前后尿流动力学和肌电图的改变。结果α-金环蛇毒可以完全抑制EUS的收缩,使SCI鼠排尿量及残余尿减少,排尿阈值降低,排尿效率得到提高,排尿压明显降低;正常鼠用药后,排尿量减少,残余尿量明显增加,排尿效率下降,排尿压没有改变。结论EUS功能对正常排尿活动是必需的,阻断SCI鼠的EUS活动则有助于改善其排尿功能,这对于治疗人类SCI后的排尿异常有借鉴意义。
Objective The detrusor- sphincter dyssynergia is the main reason of lower urinary tract dysfmactions after Spinal cord injury （SCI）. Alpha- bungarotoxin （BGT） , a highly selective neuromuscular junction blocking agent was injected into the external urethal sphincter （EUS） to detennine whether EUS relaxation improves voiding dysfunction after SCI in male rat.Methods Male Sprague- Dawley rats （250 - 300 g） with spinal cord chronically tmnsected at T9 - 10 or with normal spinal cords were used. BGT was injected directly into EUS of SCI rats or normal rats. EUS electromyograms were evaluated, including VV, RV, VT, VE, MP, and BCD before and after BGT injection. Results After BGT injection, all the animals kept normal respiration . In SCI rats, treatment with BGT completely suppressed EUS activity and improved voiding .The toxin increased VE and reduced VV, RV, MP. In normal rats, it decreased VE, increased RV but did not change MP. Conclusions BGT improves voiding in SCI rats by reducing urinary meatus resistance. However, in normal rats, the toxin reduces voiding by eliminating the activity of EUS. Drugs that depress striated muscle activity can be useful in treatment of voiding dysfunction after SCI.
出处
《武警医学》
CAS
2006年第1期31-33,共3页
Medical Journal of the Chinese People's Armed Police Force
关键词
脊髓损伤
金环蛇毒
尿动力学
Spinal cord injury Alpha- bungarotoxin Urodynamics
