摘要
目的检测Bag-1在视网膜母细胞瘤中和正常组织中的表达,并讨论其意义。方法利用组织芯片采用免疫组化S-A法检测视网膜母细胞瘤和正常组织中Bag-1的表达。结果视网膜母细胞瘤组织芯片中Bag-1在胞核,胞浆均有高表达,在正常组织中表达阳性率低。两者间存在显著性差异(P<0.05)。结论Bag-1的高表达提示其可能参与了视网膜母细胞瘤的发生。
Objective To detect Bag-1 expression in retinoblastoma and normal tissue with tissue microarray and to discuss it＇s clinical significance. Methods The experiment was done in the Laboratory of the Fourth Military Medical University of Chinese PLA between June and August 2005, Tissue microarray of retinoblastoma and normal retina tissues were used to determine the expression of Bag- 1 with immunohistochemical S-A system.Results Bag-I was detected strong expression in the nucleus and cytoplasm in the cancer tissue ,while it was hardly seen in the normal retinal cells.There were significant difference of positive rates of Bag-1 expression between the cancer tissue and the normal tissues （P 〈 0.05 ）. Conclusion There is an over expression of Bag-1 in retinoblastoma, suggesting that Bag-1 may be related to retinoblastoma,
出处
《四川医学》
CAS
2006年第3期234-235,共2页
Sichuan Medical Journal
