摘要
目的探讨胰岛素样生长因子结合蛋白1-3（IGFBP（1-3））在早孕期蜕膜和绒毛中的表达及其作用。方法选取早孕5～7周行人工流产术的蜕膜和绒毛标本共48例，每一孕周分早、中、晚三个时期，每个时期5～6例，以分泌中期（周期第21天）子宫内膜标本为对照。采用免疫组织化学LsAB法和计算机图像分析法对IGFBP（1-3）在围着床期子宫内膜、蜕膜和绒毛滋养细胞的表达进行定位和定量分析。结果IGFBP（1-3）在子宫内膜腺、腔上皮、蜕膜细胞和绒毛滋养层中都有表达，其表达在孕5～6周达峰值，与对照的分泌中期内膜比较，差异有统计学意义（P〈0．01）。结论IGFBP（1-3）在早孕期表达增强，推测可能参与了子宫内膜的蜕膜化、滋养层细胞侵袭性以及早期胚胎发育的调节过程。
Objective： To study the expression of insulin-like growth factors binding proteins 1-3 （IGFBP（1-3）） in human decidua and trophoblast and their roles during early pregnancy.
Methods： Decidua and villi were obtained from 48 healthy women at 5-7th week of pregnancy and endometrium in mid-secretory phase was obtained as control. The expression of IGFBP（1-3） was detected by immunohistochemistry （LsAB） and quantified by computer image analysis system.
Results： IGFBP（1-3） were expressed in luminal and glandular epithelium, decidual cells and trophoblast cells, which reached the peak level at 5-6th week of pregnancy, and the expression was higher than that in mid-secretory phase group （P〈0.01）. Conclusions：The expressions of IGFBP（1-3） were higher in early pregnancy. IGFBP（1-3） may have some roles in decidualization, trophoblast invasion and embryo growth during early pregnancy.
出处
《生殖医学杂志》
CAS
2006年第1期26-29,共4页
Journal of Reproductive Medicine
基金
国家自然科学基金(39970764)
四川省计划生育委员会基金(97-4-3)
关键词
胰岛素样生长因子结合蛋白
蜕膜
绒毛
Insulin-like growth factors binding proteins
Decidua
Trophoblast
