摘要
目的观察犬心脏停搏(CA)复苏后再灌注期间脑矢状窦血浆内皮素-1(ET-1)及脑氧代谢变化。方法健康杂种家犬6只,电击引起室颤(VF)性CA 8 min后,行开胸心肺复苏,在自主循环恢复后,控制通气4 h,取动脉血及脑矢状窦血行血气分析及ET-1测定,观察CA前及CA后再灌注30、60、120、240 min时的脑矢状窦血浆ET-1及脑矢状窦氧饱和度(SsO2)、氧利用率(O2UC)的变化。结果与CA前比较,脑矢状窦血浆ET-1在CA后再灌注120、240 min时显著升高(P<0.05);脑SsO2在CA后再灌注30 min时显著升高(P<0.05),但在CA后再灌注240 min时显著降低(P<0.01);脑O2UC在CA后再灌注30 min时显著降低(P<0.05),但在CA后再灌注240 min时显著升高(P<0.01)。结论CA复苏后脑循环ET-1水平升高,可能影响大脑灌注,导致脑氧代谢发生变化。
Objective To study the changes of endothelin-1 （ET-1） concentration in sagittal sinus and cerebral oxygen metabolism after cardiac arrest（CA） and resuscitation in dogs. Methods In 6 dogs, the model of ventricular fibrillation of 8 min was used to simulate the cardiac arrest, and then reperfused with open cardiopulmonary resuscitation, followed by controlled ventilation for 4 hours. ET-1 concentration in sagittal sinus, cerebral sagital sinus Oz saturation （SsO2） and O2 utilization coefficient （O2 UC） were determined before CA, and at 30,60,120, and 240 min after CA. Results ET-1 concentration in sagittal sinus was higher （P〈0.05） at 120, 240 min after arrest than that before CA. At 30 min after CA, SsO2 was higher（P〈0. 05）,but was lower at 240 min（P〈0.01） than that before CA. Cerebral O2UC was lower（P〈0.05） at 30 min but higher （P〈0.01） at 240 min after CA than that before CA. Conclusion Increased ET-1 levels in cerebral circulation may contribute to the delayed hypoperfusion, and the changes of cerebral oxygen metabolism after CA and resuscitation.
出处
《临床麻醉学杂志》
CAS
CSCD
2006年第2期134-136,共3页
Journal of Clinical Anesthesiology
基金
重庆市科委课题(2001-6831)
关键词
心脏停搏
心肺复苏
内皮素-1
脑氧代谢
Cardiac arrest
Cardiopulmonary resuscitation
Endothelin-1
Cerebral oxygen metabolism
