摘要
目的研究地塞米松对急性肺损伤(ALI)早期血管内皮生长因子(VEGF)变化的影响,为临床治疗提供理论依据。方法雄性新西兰家兔24只,随机分为对照组(N)9只,急性肺损伤组(L)8只,早期干预组(E)7只。建立内毒素ALI模型,E组于建模后一次性给予地塞米松2 mg。结果L组在内毒素注射后血压、心率、pH明显下降;血清及肺泡灌洗液(BALF)中VEGF升高。E组血压、心率降幅减小,VEGF的表达明显被抑制,肺病理改变减轻。结论地塞米松可通过抑制VEGF的表达来改善ALI早期血管通透性。
Objective To investigate the effects of dexarnethasone on vascular endothelial growth factor （VEGF） in the early stage of acute lung injury （ALI）. Methods 24 male New Zealand rabbits were divided into three groups randomly： N： the control group （ n = 9） ;L： the ALI group （ n = 8） receiving intervenous lipopolysaecaride （LPS） to achieve the degree of ALI; E： the early-intervention group （ n =7）, treated with 2 mg dexamethasone immediately after injection of LPS. Results In group ALI, blood pressure, heart rate, pH and buffer excess（BE） were markedly decreased. VEGF in serum and bronchoalveolar lavage fluid（BALF） were both higher than those in the sham ones. In group E, the blood pressure and heart rate decrease were diminished, the increase of VEGF in serum and BALF were inhibited significantly and the extent of lung pathological changes were mitigated. Conclusion Dexamethasone could improve the permeability of endothelium by inhibiting of VEGF in the early stage of ALI.
出处
《首都医科大学学报》
CAS
2006年第1期48-51,共4页
Journal of Capital Medical University
关键词
急性肺损伤
地塞米松
内毒素
血管内皮生长因子
acute lung injury
dexamethasone
endotoxin
vascular endothelial growth factor
