摘要
采用紫外分光光度法测定罗格列酮钠片的溶出度。检测波长234nm。转速50r·min-1,溶出介质为0.01mol/L盐酸500mL;罗格列酮钠在(4～20)μg·mL-1-范围内线性良好,r=0.9999(n=7),方法平均回收率99.95%(n=9),日内和日间RSD分别为0.49%及0.75%。20min定时取样测定,主药溶出95%以上。方法简便、准确,可有效的控制其质量。
To determine the dissolution of Rosiglitazone Sodium Tablet, a UV-spectrophotometric method was used to study the dissolution with the detection wavelength at 234 rim. The rotative velocity of 50r·min^-1 and the 500 mL of water. The linear range of the standard curve was（4-20）μg·mL^-1, r=0.999 9（n=7）. The average recovery of this method was 99.95%（n=9）, the within-day RSD and between-day RSD were 0.49% and 0.75% respectively. The drug dissolution rate for 20min was over 95%. This method is convenient, accurate.
出处
《科学技术与工程》
2006年第2期238-239,241,共3页
Science Technology and Engineering
关键词
罗格列酮钠片
溶出度测定
平均回收率
Rosiglitazone Sodium Tablets dissolution determination average recovery
