摘要
目的 探讨奇异性子宫平滑肌瘤的临床及病理特点。方法 对15例奇异性子宫平滑肌瘤的病因及临床表现进行分析，并作病理及免疫组化检查。结果 奇异性子宫平滑肌瘤以不规则阴道流血、盆腔包块、贫血为主要临床表现。其中3例合并妊娠，4例有孕激索治疗史。镜下见多核或单核瘤巨细胞，核分裂象0～3／10HPF。孕激素受体（PR）均呈阳性表达．其中8例Ki-67、p53呈微弱阳性表达，雌激素受体（ER）呈阴性表达。结论 奇异性子宫平滑肌瘤属良性肿瘤，临床表现及治疗与子宫平滑肌瘤相似。其发病与外源性孕酮及内源性孕激素有一定关系。与子宫平滑肌肉瘤的鉴别主要依靠苏木素伊红染色（HE）切片观察，免疫组化表达有一定的特征。
Objective To explore the clinical and pathological characteristics of singularity uterine leiomyoma. Methods The cause of disease and the clinical features in 15 patients with singularity uterine leiomyoma were analyzed. The patients were examined by pathology and immunohistochemistry. Results The main clinical manifestations were itregular vaginal bleeding, pelvic tumor and anemia. 3 patients combined with pregnancy,4 patients had the treatment history of exogenous progesterone. The tumor appeared grayish red, and with complete envelope by macroscopic examinatlon;The multi- and mono-nucleated giant cells were seen under surgical microscopy,the mitosis count was 0 ～3/10HPF. The tumors showed weak positive staining for Ki-67 and p53, negative staining for ER in 8 cases and positive staining for PR in all cases. Conclusions Singularity uterine leiomyoma belongs to benign tumor, its clinical features and treatments are similar to common leiomyoma; It has certain relation with exogenous and endogenous progesterone. The differentiation of leiomyoma with leiomyosarcoma is basically depended on HE staining observation;The immunohistochemistry of leiomyoma has certain feature.
出处
《中国基层医药》
CAS
2006年第1期76-77,共2页
Chinese Journal of Primary Medicine and Pharmacy
