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卡维地洛对慢性心衰患者心室内和心室间同步性的影响

Effects of Carvedilol upon intra-and interventricular synchrony in patients with chronic heart failure
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摘要 Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure(HF), determining left ventricular(LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes. Radionuclide isotopic ventriculography with phase analysis was performed in 30 patients with stable heart failure(HF), determining left ventricular(LV) and interventricular contraction synchrony at baseline and after 6 months of treatment with maximal tolerated doses of carvedilol. Patients with HF had significant ventricular dyssynchrony compared with a normal population. The 50th percentile of patients with the greatest dyssynchrony at baseline showed significant improvement in ventricular synchrony after receiving carvedilol, and this was correlated positively with a reduction in end-diastolic LV volumes.
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