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子宫内膜异位症患者血清金属蛋白酶-1、组织抑制因子-1检测的临床意义

Study of Matrix Metalloproteinase-1 and tissue inhibitor of Metalloproteinase-1 in serum of patients with endometriosis
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摘要 目的:探讨子宫内膜异位症患者血清金属蛋白酶-1(MMP-1)、组织抑制因子-1(TIMP-1)水平的变化及其临床意义。方法:收集44例子宫内膜异位症(EMs)患者(其中Ⅰ期8例、Ⅱ期2例、Ⅲ期20例、Ⅳ期14例)和30例对照组患者的血清,以及18例EMs患者手术加药物治疗后的血清标本,采用双抗夹心酶联免疫吸附法(ELISA)定量检测血清中MMP-1、TIMP-1的水平。结果:EMs患者血清MMP-1的水平高于对照组(P<0．05),TIMP-1的水平低于对照组(P<0．01),早期(Ⅰ-Ⅱ期)血清TIMP-1高于Ⅲ、Ⅳ期(P<0．05);手术加药物治疗后EMs患者血清TIMP-1水平可显著性提高;血清TIMP-1水平与临床分期呈直线负相关关系(P<0．01,r=-0．398)。结论:检测EMs患者血清TIMP-1的水平对EMs随访监测及评价手术药物疗效有一定价值。
作者 周小会 李兆艾
机构地区 江苏省无锡市妇幼保健院 山西省妇幼保健院
出处 《生殖与避孕》 CAS CSCD 北大核心 2005年第10期627-629,共3页 Reproduction and Contraception
关键词 子宫内膜异位症 MMP-1 TIMP-1 血清
分类号 R711.71 [医药卫生—妇产科学]
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参考文献4

  • 1Mizumoto H, Saito T, Ashihara K, et al. Expression of matrix metalloproteinases in ovarian endometriomas: immunohis-tochemical study and enzyme immunoassay. Life Sci,2002.71(3):259-73. 被引量：1
  • 2李东.血清基质金属蛋白酶类检测的临床应用[J].国外医学（临床生物化学与检验学分册）,2002,23(2):100-101. 被引量：6
  • 3Sharpe-Timms KL, Keisler LW, Mclntush EW, et al. Tissue inhibitor of metalloproteinase-1 concentrations are attenuated in peritoneal fluid and sera of women with endometriosis restored in sera by gonadotropin-releasing hormone agonist therapy. Fertil Steril, 1998, 69(6):1 128-34. 被引量：1
  • 4Koninckx PR, Kennedy SH & Barlow DH. Endometriotic disease: the role of peritoneal fluid. Hum Reprod Update,1998, 4(5):741-51. 被引量：1

二级参考文献16

  • 1Arthur MJP. Murawaki Y. Serum matrix metalloproteinase-1 in patients with chronic viral hepatitis[J]. J Gastroenterol Hepatol, 1999,14(2): 138-144. 被引量：1
  • 2Kasahara A, Hayashi N. Circulating matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-1 as serum markers of fibrosis in patients with chronic hepatitis C. Relationship to interferon response[J]. J Hepatol, 1997, 26(3):574-583. 被引量：1
  • 3Ylisirnio S, Hoyhtya M. Matrix met alloproteinases -2 ,-9 and tissue inhibitors of matalloproteinases -1,-2 in lung cancer-TIMP-1 as a prognostic marker[J]. Anticancer Res, 2000,20(2B) :1311-1316. 被引量：1
  • 4Oberg A, Hoyhtya M, Tavelin B, et al. A Limitid value of preoperative serum analyses of matrix metalloproteinases(MMP-2,MMP-9) and tissue in hibitors of matrix metalloproteinases (TIMP-1 ,TIMP-2) in colorectal cancer[J]. Gut,1998,42(5):715-720. 被引量：1
  • 5Gohji K, Fujimoto N, et al. Serum matrix metalloproteinase-2 and its density in men with prostate cancer as a new prdeictor of disease extension [J]. Int J Cancer,1998,20,79(1):96-101. 被引量：1
  • 6Endo K, Maehara Y, Baba H, et al.Elevated levels of serum and plasma metalloproteinases in patients with gastric cancer [J]. Anticancer Res,1997,17 (3C): 2253-2258. 被引量：1
  • 7Kinoshita M, Sumiya M. Serum matrix metalloproteinase-3 and fibrin degradation product levels correlate with clinical disease activity in rheumatoid arthritis[J]. Clin Exp Rheumatol, 1998,16(5): 533-540. 被引量：1
  • 8Kotajima L, Aotsuka S, Fujimani M,et al. Increased levels of matrix metalloproteinase-3 in sera from patients with active lupus nephritis[J]. Clin Exp Rheumatol, 1998, 16 (4): 409-415. 被引量：1
  • 9Matsuyama T. Tissue inhibitor of mealloproteinases-1 and matrix metalloproteinases-3 in Japanese healthy children and in Kawasaki disease and their clinical usefulness in juvenile rheumatoid arthritis[J]. Pediatr Int,1999,41(3) :239-245. 被引量：1
  • 10Nishida T. Kinetics of tissue and serum matrix metalloproteinase-3 and tissue inhibitor of matalloproteinases1 in intervertabral disc degeneration and disc herniation[J]. Kurume Med J,1999,46(1) :39-50. 被引量：1

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生殖与避孕
2005年 第10期

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