期刊文献+

β_2-肾上腺素能受体基因多态性与高血压关系的研究进展 被引量:1

下载PDF
导出
摘要 2β-肾上腺素能受体(2β-adrenergic receptor,2β-AR)是交感神经系统的重要组成部分,对血压的短期和长期调节均有重要影响。2β-AR基因作为原发性高血压(EH)重要的候选基因,其变异与受体的表达、血管紧张性的变化均有关系;同时目前已在不同人群中证实其与高血压有相关性。本文综述了该基因多态性在高血压及其他领域最新的研究进展。
作者 骆秦 李南方
出处 《国外医学(遗传学分册)》 2005年第5期277-280,共4页 Foreign Medical Sciences(Section of Genetics )
基金 国家自然科学基金(No.30260038)
  • 相关文献

参考文献30

  • 1Munakata M. Beta 2-Adrenergic receptor gene polymorphisms. Nippon Rinsho, 2001,59(10):1889-1893. 被引量:1
  • 2Svetkey LP, Chen YT, McKeown SP, et al. Preliminary evidence of linkage of salt sensitivity in black Americans at the beta-2 adrenergic receptor locus. Hypertension, 1997,29(5):918-922. 被引量:1
  • 3Gratze G, Fortin J, Labugger R, et al. β2 adrenergic receptor variants affect resting blood pressure and agonist-induced vasodilation in young adult caucasians. Hypertension, 1999,33(6):1425-1430. 被引量:1
  • 4McGraw DW, Forbes SL, Kramer LA, et al. Polymorphisms of the 5' leader cistron of the uuman β2-adrenergic receptor regulate receptor expression. J Clin Invest, 1998,102(11):1927-1932. 被引量:1
  • 5Lipworth B, Koppelman GH, Wheatley AP, et al. Beta-2 adrenoceptor promoter polymorphisms: extended haplotypes and functional effects in peripheral blood mononuclear cells. Thorax, 2002,57(1):61-66. 被引量:1
  • 6Green SA, Turki J, Innis M, et al. Amino-terminal polymorphisms of the human β2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry, 1994,33:9414-9419. 被引量:1
  • 7Hoit BD, Suresh DP, Craft L, et al. β2-adrenergic receptor ploymorphisms at a mino acid 16 differentially influence agonist-stimulated blood pressure and peripheral blood flow in normal individuals. Am Heart J, 2000,139(3):537-542. 被引量:1
  • 8Dishy V, Sofowora GG, Xie HG, et al. The effect of common polymorphisms of the β2-adrenergic receptor on agonist-mediated vascular desensitization. N Engl J Med. 2001,345(3):1030-1035. 被引量:1
  • 9Garovic VD, Joyner MJ, Dietz NM, et al. β2-Adrenergic receptor polymorphism and nitric oxide-dependent forearm blood flow responses to isoproterenol in humans. J Physiol, 2003,546(2):583-589. 被引量:1
  • 10Kotanko P, Binder A, Tasker J, et al. Essential hypertension in African Caribbeans associates with a variant of the beta2-adrenoceptor. Hypertension, 1997,30(4):773-776. 被引量:1

二级参考文献19

  • 1Kotanko P, Binder A, Tasker J, et al. Essential hypertension in African Caribbeans associates with a variant of the β2-adrenoceptor. Hypertension, 1997,30∶773-776. 被引量:1
  • 2Svetkey LP, Timmons PZ, Emovon O, et al. Association of hypertension with β2- and α2c10-adrenergic receptor genotype. Hypertension, 1996,27∶1210-1215. 被引量:1
  • 3Candy G, Samani N, Norton G, et al. Association analysis of beta2 adrenoceptor polymorphisms with hypertension in a Black African population. J Hypertens, 2000,18∶167-172. 被引量:1
  • 4Kobilka BK, Dixon RAF, Frielle T, et al. cDNA for the human β2-adrenergic receptor. Proc Natl Acad Sci U S A,1987,84∶46-50. 被引量:1
  • 5Ward R. Familial aggregation and genetic epidemiology of blood pressure. In: Laragh JH, Brenner BM,eds. Hypertension: Pathophysiology, Diagnosis and Management. New York: Raven Press, 1990.81-100. 被引量:1
  • 6Tonolo G, Melis MG, Secchi G, et al. Association of Trp64Arg beta 3-adrenergic-receptor gene polymorphism with essential hypertension in the Sardinian population.J Hypertens, 1999, 17∶33-38. 被引量:1
  • 7Bengtsson K, Melander O, Orho-Melander M, et al. Polymorphism in the β1-adrenergic receptor gene and hypertension. Circulation, 2001, 104∶187-190. 被引量:1
  • 8Maqbool A, Hall AS, Ball SG, et al. Common polymorphisms of β1-adrenoceptor: identification and rapid screening assay. Lancet, 1999, 353∶897. 被引量:1
  • 9Svetkey LP, Timmons PZ, Emovon O, et al. Association of hypertension with β2- and α2c 10-adrenergic receptor genotype. Hypertension, 1996, 27∶1210-1215. 被引量:1
  • 10Timmermann B, Mo R, Luft FC, et al. β2-adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: the Bergen blood pressure study. Kidney Int, 1998, 53∶1455-1460. 被引量:1

共引文献26

同被引文献15

引证文献1

二级引证文献2

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部