摘要
为解决经皮器械在负重条件下的长期稳定和经皮密封问题,本文对比研究了阳极氧化表面以及光滑表面的纯钛种植体经皮植入动物体内的情况,并同时将人皮肤表皮细胞接种于这两种表面上进行培养,初步探讨了阳极氧化活化处理后的纯钛金属作为经皮植入体的可能性。结果表明:经皮部分钛金属的光滑表面与阳极氧化的微观粗糙表面对于术后炎性反应的影响无明显差异,阳极氧化活化表面不仅能与骨形成牢固结合,而且也可以与皮下组织紧密贴附。同时,在体内种植体表面形成的钙磷层可能也是形成经皮密封的原因之一,阳极氧化活化钛的微孔粗糙表面对表皮也有一定的锁合固定作用。因此阳极氧化的表面活化方法有可能成为有效的解决经皮生物密封的活化方法之一。
In order to solve the problesm in biological sealing of load-bearing percutaneous implants for a fairly long time, we investigated titanium with bioactivated anodic oxidized surface （group A） through the animal tests in vivo and the epithelium cell culture in vitro. Smooth Ti （group B） was used as control. The animal tests results showed that there was no evident difference in the inflammory reaction between the group A implant/ tissues and the group B implant/tissues. The bioactivated Ti surface could keep the implant not only bonding with the bone firmly but also adhering to the soft tissue closely, thus contributing to the formation of calcium phosphate layer and its micropores. The cell culture results also demonstrated that the microporous surface of group A could clasp and fix the skin. So, it can be concluded that the surface modified method of anode oxidization may be one of the most effective methods to resolve the problem of durable biological sealing.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2006年第1期93-96,共4页
Journal of Biomedical Engineering
基金
国家"863"高技术发展计划资助项目(2001AA326010)
关键词
阳极氧化
钛
上皮移行
生物密封
Anode-oxidized Titanium Skin downgrowth Biological sealing
