摘要
目的探讨过氧化物酶体增殖物激活受体γ(PPARγ)配体罗格列酮对压力超负荷大鼠血流动力学及心肌肥厚的影响。方法30只SD大鼠随机分为假手术组(n=9)和压力超负荷模型组(n=21),应用腹主动脉缩窄的方法制作压力超负荷模型,将制作模型后24h仍存活的16只大鼠随机分为压力超负荷(PO)组(n=7)和罗格列酮(PO+Ros)组(n=9)。罗格列酮组给予罗格列酮3mg/(kg·d)共8周。8周后测定血流动力学;称量心脏质量;放射免疫分析方法测量血浆肾素活性、血管紧张素Ⅱ和醛固酮。结果与PO组相比,PO+Ros组动脉血压降低(P<0.05);±dp/dtmax升高(P<0.05);心脏质量指数和左室质量指数降低(P<0.05);血浆肾素活性、血管紧张素Ⅱ、醛固酮和胰岛素及血糖水平无明显差异(P>0.05)。结论PPARγ配体改善压力超负荷性心肌肥厚和左室舒缩功能,降低动脉血压,其效应与血浆肾素血管紧张素系统无明显关系。
[Objective] To investigate the effects of peroxisome proliferator-activated receptorγ （PPARγ） ligand rosiglitazone on hemodynamics and cardial hypertrophy in rats with pressure overload.[Metheds] Thirty SD rats were divided into sham-operated group （n=9） and pressure overload mode group （n=21）. Twenty-four hours after making pressure overload by coarctation of abdominal aorta, 16 surviving rats were randomly divided into pressure overload （PO） group （n=7） and rosiglitazone （PO＋Ros） group （n=9）. PO＋Ros group had taken rosiglitazone 3 mg/（kg·d） for 8 weeks. Specimens were taken after measuring hemodynamic indexes and heart, lung, and liver mass were measured. Plasma renin activity, angiotensin Ⅱ, and aldosterone were detected by radioimmunity. [Results] Compared with PO group, arterial blood pressure was reduced （P〈 0.05） and ±dp/dtmax were increased （P〈0.05）; heart mass index and left ventricular mass index were decreased in PO＋Ros group （P〈 0.05）. Plasma renin activity, angiotensin Ⅱ, aldosterone, and insulin as well as blood glucose had no change in three groups （P〉 0.05）. [Conclusions] PPARγ ligand rosiglitazone ameliorates cardiac hypertrophy and improve left ventricular function, reduces arterial blood pressure of rats with pressure overload independent of plasma renin angiotensin system.
出处
《中山大学学报（医学科学版）》
CAS
CSCD
北大核心
2006年第1期47-50,共4页
Journal of Sun Yat-Sen University:Medical Sciences
基金
广东省医学科研基金资助项目(B2005031)
广东省博士科研启动基金资助项目(5300704)
关键词
过氧化物酶体增殖物激活受体Γ
肥厚
左室
血流动力学
peroxisome proliferators activated receptor γ
hypertrophy, left ventricular
hemodynamics
