摘要
戊巴比妥钠对豚鼠乳头状肌电活动和机械收缩的影响张翼,谷双振,郝永昌,宋立林,郭书梅,卢慎圭(河北医科大学生理教研室,石家庄050017,中国)关键词戊巴比妥;电生理学;动作电位;乳头状肌;钾通道目的:研究戊巴比妥钠(SP)对豚鼠心室乳头状肌动作电位(...
IM: To study the effects of sodium
pentobarbital (SP) on the action potential (AP) and contraction of
guinea pig papillary muscle. METHODS: Using conventional glass
microelectrode and mechanical recording of myocardium contraction.
RESULTS: SP (≥10 μmol·L -1 ) prolonged the AP duration (APD)
and effective refractory period (ERP), while amplitude (APA) and V
max of phase 0 showed no changes. The effects of SP were abolished
by pretreatment with cromakalim, an agonist of ATP sensitive K +
channel. The maximal isometric tension ( P max ) and velocity
of tension development (d T /d t ) were decreased to 51 % and 48
% of control, respectively. The first postrest beat (B 1) and
second postrest beat (B 2) were also depressed. CONCLUSION: SP
affected the action potential by reducing activities of the K +
channels and reduced the contraction of guinea pig myocardium.
出处
《中国药理学报》
CSCD
1996年第5期439-441,共3页
Acta Pharmacologica Sinica
关键词
戊巴比妥
电生理学
动作电位
乳头状肌
钾通道
pentobarbital
electrophysiology
action potentials
papillary muscles
potassium channels