期刊文献+

戊巴比妥钠对豚鼠乳头状肌电活动和机械收缩的影响

Effects of sodium pentobarbital on electric and mechanical activities of guinea pig papillary muscle
原文传递
导出
摘要 戊巴比妥钠对豚鼠乳头状肌电活动和机械收缩的影响张翼,谷双振,郝永昌,宋立林,郭书梅,卢慎圭(河北医科大学生理教研室,石家庄050017,中国)关键词戊巴比妥;电生理学;动作电位;乳头状肌;钾通道目的:研究戊巴比妥钠(SP)对豚鼠心室乳头状肌动作电位(... IM: To study the effects of sodium pentobarbital (SP) on the action potential (AP) and contraction of guinea pig papillary muscle. METHODS: Using conventional glass microelectrode and mechanical recording of myocardium contraction. RESULTS: SP (≥10 μmol·L -1 ) prolonged the AP duration (APD) and effective refractory period (ERP), while amplitude (APA) and V max of phase 0 showed no changes. The effects of SP were abolished by pretreatment with cromakalim, an agonist of ATP sensitive K + channel. The maximal isometric tension ( P max ) and velocity of tension development (d T /d t ) were decreased to 51 % and 48 % of control, respectively. The first postrest beat (B 1) and second postrest beat (B 2) were also depressed. CONCLUSION: SP affected the action potential by reducing activities of the K + channels and reduced the contraction of guinea pig myocardium.
出处 《中国药理学报》 CSCD 1996年第5期439-441,共3页 Acta Pharmacologica Sinica
关键词 戊巴比妥 电生理学 动作电位 乳头状肌 钾通道 pentobarbital electrophysiology action potentials papillary muscles potassium channels
  • 引文网络
  • 相关文献

参考文献2

  • 1张翼,中国药理学报,1992年,13卷,338页 被引量:1
  • 2Fan Z Z,中华物理医学杂志,1991年,13卷,39页 被引量:1

相关主题

;
使用帮助 返回顶部