摘要
组胺Ｈ３受体介导抑制豚鼠心交感神经释放去甲肾上腺素的直接依据罗晓星，文爱东１，郭治安２，谭月华（第四军医大学药理教研室，１西京医院临床药理室；２西北大学化学系，西安７１００３２，中国）关键词心房；电刺激；甲基组胺；组胺拮抗剂；去甲肾上腺素；节后交感神...
IM: To study the
histamine H 3 receptors mediated inhibition of norepinephrine (NE)
release from cardiac sympathetic terminals of guinea pig isolated
atria. METHODS: Release of NE induced by electric field stimulation
(50 mA, 5 ms) in the bath solution was measured by HPLC ECD.
RESULTS: The release of NE caused by field stimulation was attenuated
by (R) α methyl￣histamine (α MeHA, 0 1 nmol·L -1 -10 μ
mol ·L -1 ) in a concentration dependent manner. Thioper￣
amide concentration dependently antago￣nized the inhibition of α
MeHA. Blockade of H 1, H 2, α 2, β 2 receptors failed to
prevent the inhibitory effect of α MeHA. Thioperamide (1 nmol·L
-1 -10 μmol·L -1 ), when used alone, concentration
dependently facilitated the release of NE evoked by field
stimulation. CONCLUSION: The presynaptic histamine H 3 receptors
inhibited the NE release from cardiac sympathetic terminals.
出处
《中国药理学报》
CSCD
1996年第5期425-428,共4页
Acta Pharmacologica Sinica
关键词
心房
电刺激
组胺
去甲肾上腺素
H3受体
heart atrium
electric stimulation
methylhistamines
histamine antagonists
nore￣pinephrine
postganglionic sympathetic
fibers
histamine H 3 receptors
high pressure liquid chromatography
