摘要
目的探讨低剂量血液透析对细胞因子及残余肾功能的影响。方法对30例有残余肾功能 Ccr>5ml/min,尿量>800ml/d 的尿毒症患者随机分为二组进行血液透析。低剂量血液透析组20例,每周透析1～1.5次;常规血液透析组10例,每周透析2～3次。结果经9个月的血液透析后,低剂量血液透析组产生的细胞因子 IL-6、IL-1、TNF-α水平低于常规血液透析组,IL-10高于常规血液透析组,且残余肾功能下降缓慢。透析充分性无显著差异。结论对有残余肾功能 Ccr>5ml/min,尿量>800ml/d每次脱水<2kg 的尿毒症患者进行每周1～1.5次低剂量血液透析是可行的。低剂量血液透析在保证透析充分的前提下,是非少尿性尿毒症的早期透析活疗方案。
Objective To investigate the effect of low-dosage hemodialysis on cytokine and residual renal function. Methods 30 uremic patients whose residual renal function could preserve（ Ccr 〉 5 ml/min urine 800 ml/d）. Were divided into two groups and then were given hemodialysis treatment. 20 patients （ experimental group ） performed in the low-dosages hemodialysis and hemodialysed 1 - 1.5 times weekly and the other 10 patients（ Routine Hemodialysis） performed routine hemodialysis,2 times weekly. Results Compared with the routine hemodialysis group ,the experiment group produced less IL-1 ,IL-6 ,TNF-α, But more、IL-10, While residual renal function declined slowly after nine months, There was no significant difference in hemodialysis effect between the two groups. Conclusion Low-dosage hemodialysis 1 - 1.5 times a week was feasible for uremic patients if their residual renal function preserred （ Ccr 〉 5 ml/min, Urine 〉 800 ml/d） and dehydration was less 2 kg on each hemodialysis. The low-dosage hemodialysis treatment is the optimal therapy for early uremia without dehydration,if the hemodialysis efficacy can be assured.
出处
《临床急诊杂志》
CAS
2006年第1期13-15,共3页
Journal of Clinical Emergency
基金
湖北省卫生厅第五个三年医药卫生科研计划项目(课题编号 WZO1582)
关键词
低剂量血液透析
细胞因子
补体
透析充分性
残余肾功能
Low-dosages hemodialysis
Cytokine
Alexin
Dialysis sufficiency
Residual renal function
