摘要
目的:观察健脾通里中药对胃癌患者术后早期免疫功能的影响和对肠屏障功能的保护作用。方法:60例将要手术的胃癌患者随机分为研究组(30例)和对照组(30例)。研究组给予术后早期(术后1 d)小肠内滴注健脾通里中药;对照组术后早期(术后1 d)小肠内滴注9.0 g/L氯化钠注射液。疗程均为7 d。手术前后分别观察:①细胞免疫功能:血白细胞介素-2(IL-2)、白细胞介素-12(IL-12)和可溶性白细胞介素-2受体(sIL-2R);②肠黏膜通透性:尿乳果糖和甘露醇比值(L/M)和血内毒素水平(ET)。结果:①术后7 d研究组与对照组比较,IL-2显著升高,sIL-2R显著降低(P<0.05);研究组自身术后7 d与术前1 d比较,IL-2、sIL-2R、IL-12水平均有显著改善(P<0.05);对照组术后7 d上述指标虽然也有所恢复,但无显著性差异(P>0.05);②研究组术后5 dL/M比值明显低于对照组(P<0.01);研究组自身术后5 d与术前1 d比较,L/M比值无明显升高(P>0.05);而对照组自身术后5 d与术前1 d比较,L/M比值明显升高(P<0.01)。③术后3d研究组血ET较对照组显著降低(P<0.01);研究组术后3 d与自身术前1 d比较,ET无显著升高(P>0.05);而对照组术后3 d与术前1 d比较,ET显著升高(P<0.01)。结论:胃癌术后早期采用健脾通里中药治疗能够提高机体免疫功能,并有助于改善肠黏膜通透性、保护肠黏膜屏障。
Objective： To observe the effects of traditional Chinese prescription for invigorating the spleen and purging the gastrointestinal tracts on the cellular immune function and intestinal mucosal barrier function in early postoperative patients with gastric cancer. Method： Sixty gastric cancer patients with operation indication were randomized into the observation group and the control group. Thirty patients were dripped with traditional Chinese prescription for invigorating the spleen and purging the gastroinstestinal tracts via the silicon catheters intubated into small intestine on the first postoperative day for 7 days, while the other 30 patients of the control group were dripped with 9.0 g/L normal saline on the first postoperative day, and the course of treatment was the same as that of the observation group. The observation parameters included cellular immune function, such as serum interleukin-2 （ IL-2 ）, soluble interleukin-2 receptor （sIL-2R） and interleukin-12 （ IL-12 ） and intestinal mucosal permecbility, such as lactulose and mannitol excretion ratio in urine as well as serum endotoxin before and after surgery. Result： The IL-2 level of the observation group increased significantly, while the level of sIL-2R de- creased obviously as compared with that of the control group seven days after operation （ P 〈 0.05 ） . The levels of IL-2, sIL-2R and IL-12 of the observation group were obviously improved seven days after operation as compared with those one day before operation. While the above-mentioned indexes of the control group showed no significant difference between seven days postoperative and one day preoperative （P 〉 0.05 ）. The excretion ratio of urine L/M of the observation group five days after operation was significantly lower than that of the control group （ P 〈 0.01 ）. But there was no significant difference in the observation group between five days postoperative and one day preoperative （ P 〉 0.05 ）. While the urine L/M excretion ratio obviously incr
出处
《安徽中医学院学报》
CAS
2006年第1期7-11,共5页
Journal of Anhui Traditional Chinese Medical College
基金
国家中医药管理局基金项目(00-01LP01)
安徽省教育厅自然科学基金项目(JL148)
关键词
胃癌
手术疗法
术后并发症
芪黄煎剂
免疫功能
肠黏膜通透性
Gastric carcinoma
Therapy of operation
Qihuang Jianji
Immune function
Intestinal mucosal permeability
