摘要
以6-氨基青霉烷酸为起始原料,经重氮化、溴化、氧化、还原、成盐制备β-内酰胺酶抑制剂舒巴坦钠,精选出合适的工艺条件,提高了成品的收率,使总收率达72.4%;整个过程反应条件温和,操作简单,适合大生产的要求。
Sulbactam sodium, α,β-lactamase inhibitor, was synthesized from 6-amino-peniciUanic acid by diazotization, bromination, oxidation, reduction and salt formation under suitable conditions. The total yield was 72.4 % and procedure was practical.
出处
《化学世界》
CAS
CSCD
北大核心
2006年第2期99-101,共3页
Chemical World
基金
浙江省自然科学基金资助项目(M203115)
