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慢性肾衰竭患者的血同型半胱氨酸水平分析 被引量:6

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摘要 目的:观察慢性肾衰竭患者的血同型半胱氨酸(Hcy)水平,分析同型半胱氨酸水平的高低与心脑血管并发症的关系。方法:选择CRF患者60例(其中30例进行血透,30例非透析治疗)和90例健康对照组及20例脑梗死对照组,测定其Hcy、肾功能、血糖、血脂、肝功能,及透析组患者服用叶酸和维生素B128周前后Hcy水平。结果:CRF患者血浆Hcy水平非透析组为28.33±14.27,透析组22.72±15.20,均明显高于正常对照组7.65±3.82(P<0.01)。伴有心脑血管病变者血浆Hcy水平39.19±14.79明显高于无心脑血管病变者血浆Hcy水平18.07±6.10(P<0.01)。相关因素分析,Hcy水平对心脑血管疾病的发生有显著影响。透析组患者服用叶酸和维生素B128周前后Hcy水平分别为22.72±15.2,11.86±7.15(P<0.05)。结论:CRF患者普遍存在高同型半胱氨酸血症,其血浆Hcy水平的升高为心脑血管疾病的独立危险因子。服用叶酸维生素B可以减少Hcy水平,从而减少心脑血管并发症。
出处 《中国中西医结合肾病杂志》 2006年第1期37-38,共2页 Chinese Journal of Integrated Traditional and Western Nephrology
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