摘要
目的检测结直肠癌患者血清上皮型钙黏附蛋白(Epithelial Cadherin,E-cd)含量的变化及其与结直肠癌病理特征的关系。方法采用ELISA法分别检测72例结直肠癌患者,38例结直肠腺瘤息肉患者,32例结肠炎患者及30位正常对照者,并分别检测结直肠癌手术切除后1周与1个月的58例与52例患者,血清中E-cd的含量。同时观察72例结直肠癌患者E-cd含量与结直肠癌病理特征的关系。结果与正常对照组比较,结直肠腺瘤息肉组血清E-cd含量显著增加(P<0.05),而结肠炎组E-cd含量虽增加但差异无显著性(P>0.05)。结直肠癌组较正常对照组血清E-cd含量显著升高(P<0.01),结直肠癌术后一周组血清E-cd含量较术前显著降低(P<0.01),但仍显著高于正常对照组(P<0.05),而结直肠癌术后一月组血清E-cd含量与正常对照组差异无显著性(P>0.05)。结直肠癌组血清E-cd含量与肿瘤分化程度、病理分期分别呈显著正相关性,而与病变部位无关。结论血清E-cd含量变化与结直肠癌的发生,发展密切相关,可作为一种新的结直肠癌标志物,对判断预后有一定意义。
【Objective】 To study the change of epithelial cadhcrin （E-cad） level in serum in patients with colorectal carcinoma and relation between serum E-cad level and its pathological characteration. 【Methods】 Serum E-cad levels in 38 patients with colorectal adenoma polyps, 32 patients with colitis, 72 patients with colorectal carcinoma and 30 normal controls were measured by ELISA technique respectively. One weck and one month after colorectal carcinoma resection, serum E-cad levels in 58 and 52 patients were also measured respectively. Meanwhile, the relation between serum E-cad levels and pathologic characterization in 72 patients with colorectal carcinoma was observed. 【Results】 Except colitis group and one month after resection group, serum E-cd levels in other groups, especially in colorectal carcinoma group, were signiticantly higher than those in normal contrals. Serum E-cd levels in colorectal carcinoma group presented high correlation with pathologic charactcrization. 【Conclusion】 Serum E-cad level is suggested to be a new valuable colorectal carcinoma marker and its change is of value in evaluating the prognosis of colorectal carcinoma.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2006年第2期270-272,275,共4页
China Journal of Modern Medicine
关键词
E-CD
血清
ELISA
结肠癌
epithelial adhering
serum
ELISA
colorectal carcinoma
