摘要
测定了80例2型糖尿病和30例正常对照组的血脂谱、空腹血糖(FBG)、糖化血红蛋白(HbAlc)、空腹胰岛素(FISN)、胰岛素敏感指数(ISI)等指标并进行比较分析,将糖尿病患者分为:非糖尿病视网膜病变组(NDR)、背景期DR(BDR)及增殖期DR(PDR)。结果表明:与正常对照组比较,糖尿病各组HbAlcF、INS、FBG、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL)、载脂蛋白-B(Apol-B)、载脂蛋白-A/B显著升高(P<0.05或0.01),ISI、高密度脂蛋白(HDL-C)则明显降低(P<0.05或0.01),各组之间载脂蛋白-A1(Apol-A1)含量无显著性差异(P>0.05);糖尿病各组间进行两两比较,TG、HbAlc在NDR组、BDR组、PDR组中逐渐升高,ISI则依次降低(P<0.05),BDR组、PDR组FINS明显高于NDR组(P<0.05),但PDR组和BDR组之间差异无显著性(P>0.05),各糖尿病组间的FBG、TC、LDL、Apol-B、Apol-A/B无显著性差异(P>0.05)。说明脂代谢紊乱及胰岛素抵抗可能与2型糖尿病视网膜病变关系密切。
The content of serum lipid, FBG, FISN, HbAlc were measured in 30 nomal cotrol subjects and 80 patients with type 2 diabetics mellitus who were divided into diabetic retinopathy group（PDR）, background-diabetic retinopathy group（BDR）, non-diabetic retinopathy group（NDR）. Insulin resistance index（ISI） were also determined. These data were analysed by SPSS for windows of 11.0. Result：The mean levels of HbAlc, FINS, FBG, total triglyceride（TG）, total cholestrerol（TC）, low-density lipoprotein （LDL）, apoprotein-B （ Apol-B ）, Apol-A/B was significantly higher in diabetic group than those in cotrol group（ P 〈0. 01,0. 05）. ISI, high-density lipoprotein （HDL-C） were significantly lower in diabetic group than those in cobol group（ P 〈0.01,0.05）, Apol-Al in the two groups was similar （ P 〉 0.05）.The content of TG,HbAlc was increased one by one（ P 〈 0.05） in NDR, BDR,PDR,the value of ISI was deceased by turns （ P 〈 0. 05）, FISN in the PDR, BDR was higher than those in NDR （ P 〈 0. 05）, but there was no differences between PDR groups and BDR groups （ P 〉0. 05 ）, FBG, TC, LDL, Apol-B, Apol-A/B among the three diabetic groups were similar （ P 〉 0.05）. Conclusion： Both abnomal metabolism of serum lipid and lipoprotein and insulin resistance probably play a significant function in the patients with diabetic retinopathy.
出处
《石河子大学学报（自然科学版）》
CAS
2005年第6期715-718,共4页
Journal of Shihezi University(Natural Science)
