摘要
许多疾病的发病与环境因素以及个体对解毒酶的遗传易感性相关,N-乙酰基转移酶-2突变导致酶活性功能减少。本文就代谢酶NAT2基因多态性与肿瘤、帕金森病、阿尔茨海默病遗传易感性进行综述。
Pathogenesis of many diseases is connected with influence of environmental factors and individual genetic sensitivity to detoxification enzynms. Mutations of N-acetyltransferasc 2 lead to decreased enzyme function. In this review, correlation between the polymorphie N-acetyltransferase-2 and Genetic susceptibility to cancer, Parkinson＇disease and Alzheimer＇s disease is summarized.
出处
《医学综述》
2006年第1期20-21,共2页
Medical Recapitulate
关键词
N-乙酰基转移酶
多态性
遗传易感性
N-acetyltransferase
Genetic susceptibility
Genetic polymorphism
