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CD105与肿瘤血管形成 被引量：1

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摘要 CD105(endoglin,EDG)为细胞膜糖蛋白,是转化生长因子-β(TGF-β)受体超家族的组成成分。调节细胞对TGF的反应,在血管生成的各种组织及肿瘤组织边缘部分血管起源的内皮细胞中高表达是新生血管的标志,而新生血管生成是实体肿瘤普遍存在的特征,CD105与肿瘤的生长、浸润、转移密切相关,可能成为某些肿瘤诊断治疗的重要靶分子之一。
作者 王艳芬 王东林
机构地区 南通大学基础医学院病理解剖学教研室
出处 《南通大学学报（医学版）》 2006年第1期75-76,共2页 Journal of Nantong University(Medical sciences)
关键词 肿瘤 新生血管 CD105 转化生长因子-Β
分类号 R730.231 [医药卫生—肿瘤]
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参考文献18

  • 1[1]Seon BK,Matsuno F,Haruta Y,et al.Longlasting complete inhibition of human solid tumors in SCID mice by targeting endothelial cells of tumor vasculature with antihuman endoglin immunotoxin[J].Clin Cancer Res,1997,3:1031. 被引量：1
  • 2[2]Li DY,Sorensen LK,Brooke BS,et al.Defective angiogenesis in mice lacking endoglin[J].Science,1999,284:1534. 被引量：1
  • 3[3]Fonsatti E,Del Vecchio L,Altomonte M,et al.Endoglinn:An accessory component of the TGF-beta 1 -binding receptor-complex with diagnostic,prognostic,and bioimmunotherapeutic potential in human malignant[J].J Cell Physiol,2001,188 (1):1. 被引量：1
  • 4[4]LiC,Hampson IN,Hampson L,et al.CD105 antagonizes the inhibitory signaling of transforming growth factor betal on human vascular endothelial cells[J].FASEB J,2000,14(1):55. 被引量：1
  • 5[5]ArthurHM,UreJ,Smith AJ,et al.Endoglin,anancillary TGF-beta-receptor,is required for extraembryonic angiogenesis and plays a key role in heart development[J].Dev Biol,2000,217 (1):42. 被引量：1
  • 6[6]Bourdeau A,Faughnan ME,Letarte M.Endoglin -deficient mice,a unique model to study hereditary hemorrhagic telangiectasia[J].rends Cardiovasc Med,2000,10(7):279. 被引量：1
  • 7[7]Tanaka F,Otake Y,Yanagihara K,et al.Evaluation of angiogenesis in non-small cell lung cancer:comparison between anti-CD34 antibody and anti-CD105 antibody[].Clin Cancer Res,2001,7:3410. 被引量：1
  • 8[8]Miller DW,Graulich W,Karges B,et al.Elevated expression of endoglin,a component of the TGF-beta -receptor complex,correlates with proliferation of tumor endothelial cells[J].Int J Cancer,1999,81 (4):568. 被引量：1
  • 9[9]Fonsatti E,Jekunen AP,Kairemo KJ,et al.Endoglin is a suitable target for efficient imaging of solid tumors:in vivo evidence in a canine mammary carcinoma model[J].Clin Cancer Res,2000,6(5):2037. 被引量：1
  • 10[10]Akagi K,IkedaY,SumiyoshiY,et al.Estimation of angiogenesis with anti-CD105 immnostaing in the process of colorectal cancer development[J].Surgery,2002,131 (1 Suppl):S109. 被引量：1

二级参考文献9

  • 1Li DY, Sorensen LK, Brooke BS, et al. Defective angiogenesis in mice lacking endoglin. Scinece, 1999, 284: 1534-1537. 被引量：1
  • 2Miller DW, Graulich W, Karges B, et al. Elevated expression of endoglin, a component of the TGF-beta-receptor complex, correlates with proliferation of tumor endothelial cell. Int J Cancer, 1999, 81:568-572. 被引量：1
  • 3Wikstrom P, Lissbrant LF, Stattin P, et al. Endoglin (CDI05) is expressed on immature blood vessels and is a maker for survival in prostate cancer. Prostate, 2002, 51:265-275. 被引量：1
  • 4Fonsatti E, Del Vecchio L, Altomonte M, et al. Endoglin: an accessory component of the TGF-beta-binding receptor-complex with diagnostic,prognostic, and bioimmunotherapeutic potential in human malignancies.Cell Physiol, 2001, 188: 1-7. 被引量：1
  • 5Dales JP, Garcia S, Bonnier P, et al. CDI05 expression is a maker of high metastatic risk and poor outcome in breast carcinonms. Correlation between immunohistochemical analysis and long-term follow-up in a series of 929 patients. Am J Clin Pathol,2003, 119:374-380. 被引量：1
  • 6Kumar S, Ghellal A, Li C, et al. Breast carcinoma: vascular density determined using CDI05 antibody correlates with tumor prognosis.Cancer Res, 1999, 59:856-861. 被引量：1
  • 7Takahashi N, Kawanishi-Tabata R, Haba A, et al. Association of serum endoglin with metastasis in patients with colorectal, breast, and other solid tumors, and suppressive effect of chemotherapy on the serum endoglin. Clin Cancer Res, 2001, 7: 524-532. 被引量：1
  • 8Tabata M, Kondo M, Haruta Y, el al. Antiangiogenic radioimmunotherapy of human solid tumors in SCID mice using ( 125 ) I-labeled antiendoglin monoclonal antibodies.Int J Cancer, 1999, 82:737-742. 被引量：1
  • 9姚欣,刘岩雪,张莉,陈华,李文录,畅继武,马腾骧.人膀胱移行细胞癌TGFβ1及其受体的表达意义[J].中华肿瘤杂志,2002,24(2):158-158. 被引量：3

共引文献14

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南通大学学报（医学版）
2006年 第1期

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