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169例闭经患者的遗传学及临床研究 被引量:3

The cytogenetic and clinic studies of 169 patients with amenorrhea
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摘要 目的:分析闭经患者的染色体核型,探讨性染色体异常对性腺发育的影响及其与临床表现的关系。方法:对169例闭经患者进行常规妇科检查及外周血淋巴细胞染色体培养和G显带分析。结果:共检出37例性染色体异常患者,异常率为21.9%,其中X染色体数目异常16例,结构异常9例,X染色体数目异常合并结构异常5例,含Y染色体有7例。结论:性染色体异常是闭经的主要原因之一;对闭经患者进行染色体检查对确定其病因及治疗具有重要意义。 Objective: To analyze the chromosomal karyotypes of the patients with amenorrhea , to discuss the correlation between sex chromosomal abnormalities and gonadal dysgenesis. Methods: 169 patients were examined by routing gynecologic examination, and their peripheral blood lymphocytes were cultured for chromosome, G - banding. If necessary, endocrine and ultrasound examination were performed. Results: 37 patients with chromosomal abnormalities were found, the ratio was 21.9%, including 16 patients with X -chromosome aneuploidies, 9 patients with structural abnormalities, 5 patients with X -chromosome aneuploidies and structural abnormalities, 7 patients karyotypes were 46, XY. Conclusion: Sex chromosome abnormalities is one of the main factors of amenorrhea. The examination of chromosome are necessary for therapy and determination of amenorrhea pathogeny.
出处 《中国妇幼保健》 CAS 北大核心 2006年第2期250-251,共2页 Maternal and Child Health Care of China
关键词 闭经 细胞遗传学 性染色体异常 Amenorrhea Cytogenetics X - chromosome abnormalities
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